Although the health impacts of fine particulate matter (PM2.5) are primarily attributed to its chemically diverse composition rather than to mass concentration, assessing the toxicity of PM2.5 constituent compounds remains highly challenging due to c... read more
BACKGROUND: Systemic inflammation in chronic obstructive pulmonary disease (COPD) presents significant therapeutic challenges. Our study employs integrated transcriptomic and single-cell analyses to identify inflammation-related biomarkers and elucid... read more
BACKGROUND: The exponential growth of Big Qualitative (Big Qual) data in healthcare research presents methodological challenges for traditional analysis approaches. This study evaluates the effectiveness of machine-assisted analysis using artificial ... read more
Modern football prioritizes team play and tactical strategies over individual brilliance. However, its low-scoring nature makes evaluating team performance challenging. Unpredictable ball movement enhances offensive play while complicating defensive ... read more
Deep neural networks can classify ECGs with high accuracy when training data is abundant. Rare conditions like Brugada syndrome, an inherited arrhythmia syndrome predisposing to sudden death, pose challenges due to data scarcity hindering model train... read more
European journal of preventive cardiology
Feb 25, 2026
Cuffless blood pressure (BP) monitoring devices represent a promising innovation in hypertension management. This scientific statement provides a comprehensive update on these emerging technologies, their specific validation requirements, their poten... read more
Protein deletions are frequent among both disease-causing and tolerated variants. Several mechanisms at the DNA, RNA and protein levels can lead to deletions. Many deletions are misclassified in the literature and databases, especially when the mRNA ... read more
The expansion and potentiation of regulatory T cells (Treg cells) offer an appealing approach for achieving immune tolerance and controlling overactive immune responses across a range of diseases. Current therapeutic approaches to expanding and impro... read more
Understanding macromolecular structures of proteins and nucleic acids is critical for discerning their functions and biological roles. Advanced techniques-crystallography, nuclear magnetic resonance, and cryo-electron microscopy-have facilitated the ... read more
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