Urban management faces unprecedented challenges in addressing uncertainty, maintaining ecological balance, and safeguarding social welfare. Despite artificial intelligence (AI) providing opportunities while also posing risks, empirical evidence of it... read more
Alzheimer's disease is a slow, progressive neurological disorder that impacts the brain tissue and causes cells to die, the most common reason for dementia. It typically reduces brain volume, subsequently impairing several cognitive functions. We exp... read more
We introduce a workflow that integrates BioEmu-generated conformational ensemble with physics-based molecular simulations and Markov State Models to sample Boltzmann-weighted conformational populations across biomolecules. Molecular simulations initi... read more
Neural progenitor cell (NPC) transplantation holds immense promise for neurodegenerative and traumatic central nervous system (CNS) pathologies. However, it is crucial to define which neural circuits and pathways are targeted with transplanted NPCs u... read more
Mobile genetic elements and genomic islands (GIs) frequently encode antibiotic resistance and host-adaptation cargo, yet routine genome comparison pipelines often miss the higher-order organization of how genes co-occur as transferable, GI-anchored m... read more
Single-cell RNA sequencing enables high-resolution characterization of cellular heterogeneity, yet integrating datasets from diverse sources remains challenging due to batch effects. Current methods rely on implicit feature disentanglement and and la... read more
Primary central nervous system lymphoma (PCNSL) is a subtype of diffuse large B-cell lymphoma (DLBCL) with confined CNS growth. We evaluated tumor microenvironment (TME) features associated with its unique tropism. Comparative spatial transcriptomic ... read more
Identifying physiological sweet spots (optimal ranges for homeostasis) is essential for precision medicine. However, traditional statistical methods often rely on globally linear or locally jagged models that struggle to capture the smooth, non-linea... read more
This study integrates three literatures typically examined in isolation: single-concept semantics, combinatorial semantics, and theory of mind (ToM). We argue that these domains share overlapping computational principles and neuroanatomical networks.... read more
Across minimal neural networks and small transformer models, we demonstrate that experience ordering alone can produce durable, irreversible behavioral divergence in artificial agents - but only when learning is consolidated into internal parameters ... read more
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