Probiotic therapeutics are evolving from generalized wellness supplements to precision Live Biotherapeutic Products aimed at specific disease targets. This review elucidates the multi-layered mechanistic framework of probiotic action, which spans eco... read more
Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study leverages deep learning and pre-trained protein language models (pLMs) to uncover allergenic SPs in me... read more
PURPOSE: Ensemble machine learning (ML) demonstrated potential for improving predictions based on big health care data. We developed and validated interpretable ensemble ML models in evaluating the nonadherence and nonpersistence of biological or tar... read more
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Feb 20, 2026
BACKGROUND: Hepatitis E virus (HEV) infection remains a major cause of liver failure with high short-term mortality, yet predictive models incorporating systemic metabolic factors are limited. AIMS: We aimed to develop a machine learning model incorp... read more
RATIONALE AND OBJECTIVES: This study aims to evaluate whether radiomics methods used on breast mammography (MG) and ultrasound (US) could distinguish between benign and borderline/malignant phyllodes tumors (PTs). MATERIALS AND METHODS: A total of 36... read more
RATIONALE AND OBJECTIVES: Preoperative prediction of microvascular invasion (MVI) in combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains difficult, and externally validated CT-based tools are scarce. To develop and externally validate a mul... read more
RATIONALE AND OBJECTIVES: TheĀ non-invasiveĀ biomarkers for predicting progression-free survival (PFS) in patients with hepatocellular carcinoma (HCC) treated with immunotherapy and molecular targeted therapy combined with transarterial chemoembolizati... read more
PURPOSE: Hypervascular pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP) represent a classic diagnostic mimicry on contrast-enhanced ultrasound, as both exhibit similar arterial-phase hyperenhancement, precluding reliable vi... read more
PURPOSE: To clarify overlapping post-market obligations under the EU Artificial Intelligence Act (AIA) and EU Medical Device Regulation (MDR) for high-risk artificial intelligence (AI) Software as a Medical Device (SaMD), and to map the regulatory la... read more
PURPOSE: Accurate preoperative prediction of preserved renal parenchymal volume (RPV) following partial nephrectomy (PN) is critical for individualized postoperative management. However, current assessment approaches remain limited in precision and g... read more
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