Cognitive function, psychological processes, mental states, and behaviors are key dimensions of human subjective experience that separately relate to mental disorders across diagnostic categories. However, whether these dimensions are linked to commo... read more
Detecting signatures of positive selection in genomes is a common application of population genetics and one of the most influential models for this task is the hard selective sweep where a de novo mutation rapidly fixes. Many statistics have been de... read more
Understanding how perturbations influence gene function in a tissue-specific manner is key to uncovering novel drug targets. However, current computational approaches emphasize global network or sequence-derived features over context-driven dependenc... read more
How habitual diet influences the gut microbiome and plasma metabolome across insulin resistance states remains unclear. We conducted year-long multi-omics profiling of 71 deeply phenotyped adults, integrating repeated assessments of diet, metabolome,... read more
Chest radiography (CXR) is a primary modality for assessing cardiopulmonary conditions, but its effectiveness is limited by anatomical obstructions (e.g., ribs, clavicles) that hinder accurate pneumothorax segmentation, boundary delineation, and seve... read more
Standard approaches to bacterial phenotyping often treat the entire genome as the fundamental unit of information, resulting in high-dimensional inputs that may contain significant redundancy. Consequently, current bacterial phenotyping techniques ty... read more
Visual hallucinations (VHs) occur across psychedelic states and diverse psychiatric and neurological conditions, yet their phenomenology remains difficult to characterise. Empirical research on VHs is hindered by the lack of large-scale phenomenologi... read more
The recurrence rate following complete surgical resection of primary non-small cell lung cancer is as high as 55%, yet no approach currently exists to evaluate the risk of local recurrence. The premetastatic paradigm is the recognition that metastasi... read more
Drug-target interaction (DTI) prediction is a key task for computed-aided drug development that has been widely approached by deep learning models. Despite extremely high reported performance, these models have yet to find widespread success in accel... read more
Biomedical Knowledge Graphs (BKGs) offer integrative representations of complex biology, yet their utility is compromised by the limitations of current construction methods: manual curation offers high fidelity but is unscalable, whereas purely autom... read more
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