Recently developed deep learning-based tools can effectively generate structural models of complexes of proteins and non-proteinaceous compounds. While some of their predictive capabilities are truly exciting, others remain to be thoroughly tested. H... read more
Fruit size and shape, which influence horticultural quality, are determined by the number and the size of the cells in the local region. In fruit trees, however, the difficulty of applying molecular genetic approaches has hindered a detailed understa... read more
Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent hepatic condition caused by the buildup of fat in the liver. It is frequently associated with metabolic comorbidities such as hypertension, cardiovascular disease (CVD), and prediabete... read more
Background and Aims: Alcohol use disorder (AUD) remains a major public health concern, with persistent disparities in access to evidence-based treatment. This study aimed to examine associations between perceived discrimination in healthcare settings... read more
Machine learning adoption in clinical decision support systems remains limited by concerns about transparency and robustness. Causal structure learning (CSL) combined with expert knowledge may address these concerns by identifying potentially causal ... read more
The Updated Sydney System (USS) provides a standardized framework for grading gastritis and stratifying gastric cancer risk. However, subjective observer variability and labor-intensive workflows impede its routine clinical use. To address these chal... read more
Abstract. Genetic diagnosis remains a formidable challenge characterized by a diagnostic odyssey that spans years, with over half of rare disease patients remaining undiagnosed affecting more than 300 million people on earth. Clinicians must navigate... read more
Artificial intelligence (AI) based segmentation has many medical applications but limited curated datasets challenge model training; this study compares the impact of dataset annotation quality and quantity on whole liver AI segmentation performance.... read more
Hypothalamic-pituitary-adrenal axis (HPA axis) dysregulation is a risk factor for poor mental and physical health. Animal studies indicate that DNA methylation may be one mechanism through which stress can influence the function of the HPA axis, howe... read more
Perinatal depression (PD) is common and disabling, yet its longitudinal comorbidity patterns and predictability remain poorly understood. This study leveraged 8,804 women with delivery records in the All of Us cohort, including 438 with clinically di... read more
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