Microwell microfluidics has emerged as powerful platforms for high precision biological and chemical investigations, bridging microscale fluid handling with compartmentalized reaction environments. Achieving robust and reproducible performance in suc... read more
Spatial attention is often partitioned into endogenous, exogenous, and social forms, yet it remains unclear whether a single neural circuit can support all three and how their population codes are organized. Here we trained recurrent artificial neura... read more
We present p-Brain, an end-to-end neuroimaging analysis framework for reproducible, automated quantitative DCE-MRI analysis at scale. From standard acquisitions, p-Brain estimates baseline relaxation parameters, converts signal to gadolinium concentr... read more
Computational prediction of blood-brain barrier (BBB) permeability has emerged as a vital alternative to traditional experimental assays, which are often resource-intensive and low-throughput to meet the demands of early-stage drug discovery. While e... read more
Foundational models that learn the language of molecules are essential for accelerating the material and drug discovery. These self-learning models can be trained on a large number of unlabelled molecules, enabling applications like property predicti... read more
Understanding continuous conformational variability of biomolecular complexes at atomic resolution is essential for linking structure to function, but remains challenging for cryo-electron tomography (cryo-ET) data due to high noise and missing-wedge... read more
Recent advances in spatial omics enable high-resolution, multiplexed in situ imaging of gene and protein expression. A major challenge in analyzing these data is cell annotation, especially in complex tissues with limited molecular markers, overlappi... read more
Signal detection theory posits that subjects in two-stimulus, two-choice discrimination tasks decide by comparing random samples of an evidence variable to a static decision criterion. While the core assumptions of the theory have received ample expe... read more
Accurately predicting chemotherapy response remains a major challenge in precision oncology. Although machine-learning models based on tumour omics data have shown promise, the majority of existing studies are trained and evaluated on pre-clinical ce... read more
Accurate identification of CRISPR arrays is essential for studying prokaryotic adaptive immunity, yet existing tools struggle with short-read sequencing data and arrays containing degenerate repeats. These limitations restrict CRISPR analysis in meta... read more
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