Background: Risk screening for pre-eclampsia relies on accurate gestational age assessment, but routine access to ultrasound-based gestational dating remains challenging in many low- and middle-income countries (LMICs). As part of the formative work ... read more
Background & Aims: Intrahepatic biliary epithelial cell (BEC) heterogeneity remains challenging to define. Here, we sought to identify BEC subpopulations and biomarkers in mouse liver. Methods: We performed scRNA-seq on Sox9EGFP+ liver epithelium fro... read more
The predictive coding framework offers a compelling model for temporal signal processing in the cortex. Recent studies explored its implementation in spiking architectures using Hebbian plasticity rules or offline learning; however, a biologically in... read more
Subjective valuation of food rewards guides our dietary choices and is fundamental to human health and well-being. Extensive literature in human functional magnetic resonance imaging (fMRI) studies has consistently shown that a network of reward-proc... read more
Climate change is expected to alter species assemblages by affecting the outcome of competition between species. Investigating processes of competition remains challenging particularly in tree communities, as they unfold over extensive spatio-tempora... read more
Predicting the kinetic pathways of biomolecular systems at all-atom resolution is crucial for understanding protein function and drug efficacy, yet this task is hindered by the immense computational cost of conventional molecular dynamics (MD) simula... read more
TAR DNA-binding protein 43 (TDP-43) aggregation is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Recent therapeutic efforts have highlighted the potential of small molecules cap... read more
Small interfering RNAs (siRNAs) are largely modified with chemical molecules to enhance their properties for use in molecular biology research and therapeutic applications. Toxicity effects may arise due to these chemical moieties as well as sequence... read more
Bedaquiline resistance is emerging globally and threatens the effectiveness of the novel short all-oral regimens for rifampicin-resistant tuberculosis. Following a systematic literature review, we quantified 13 sequence, biochemical, and structural f... read more
Artificial microRNAs (amiRNAs) offer a powerful strategy for targeted gene silencing, but their rational design is limited by complex sequence-structure-processing relationships and the lack of tools capable of optimizing efficacy and specificity. To... read more
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