ABSTRACT Objectives: To quantify patterns of preventable death in Australian coronial findings, measure government compliance with coroner recommendations across jurisdictions, and identify case characteristics associated with recommendation issuance... read more
Lung cancer is the leading cause of cancer-related mortality worldwide, predominantly affects older individuals, with non-small cell lung cancer (NSCLC) comprising 85% of cases. Despite advancements in diagnosis and treatment, prognosis for elderly p... read more
Recent advances in machine learning (ML)-based protein design methods have enabled the rapid in silico generation of large libraries of miniprotein binders with minimal manual input. While computational design capacity has scaled rapidly, experimenta... read more
Cancer evolution is driven by complex changes in gene expression as cells transition and change states during tumorigenesis. Single-cell RNA sequencing has provided snapshot insights into how the transcriptomics of tumors evolve, but whether the exis... read more
Accurately characterising mosquito infection dynamics is essential for effective dengue prevention and control, yet these dynamics are rarely observable through routine surveillance. Here, we integrate a reduced SI-SIR transmission model with monthly... read more
Integrating the cellular resolution of single-cell RNA sequencing (scRNA-seq) with the phenotypic depth of population-scale biobanks is essential for elucidating the cellular basis of complex diseases. However, this integration is often hindered by t... read more
Liquid chromatography coupled to mass spectrometry (LC/MS) is a powerful tool in metabolomics research, generating tens-of-thousands of signals from a single biological sample. However, current software solutions for unbiased assessment of metabolomi... read more
Norepinephrine (NE) is an important mediator of sympathetic activity that influences breathing. At the level of the inspiratory neural network, the preBotzinger complex (preBotC), NE modulation orchestrates changes in neuronal network dynamics that i... read more
Conventional two-dimensional (2D) histology relies upon destructive sample preparation and stereological estimation, frequently leading to sampling bias and loss of critical spatial context required for understanding renal structure relationships. He... read more
The variety of cell phenotypes identified by single-cell technologies is rapidly expanding, yet this knowledge is dispersed across the scientific literature and incompletely represented in structured resources. We present the CellLink corpus, a manua... read more
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