The precise modulation of reactive oxygen species (ROS) generation pathways is crucial for enhancing the selectivity and efficiency of piezo-catalytic water purification. Herein, we report a mechanism-informed machine learning (ML) strategy integrati... read more
Cardiotoxicity is a significant challenge in cancer therapies, particularly with doxorubicin, a widely used anthracycline. More predictive in vitro models are needed to understand doxorubicin-induced cardiac damage and patient-specific responses. Her... read more
BACKGROUND: Extrachromosomal circular DNA (eccDNA) is increasingly recognized as a critical driver of oncogene amplification, therapeutic resistance, and intratumoral heterogeneity in cancer. However, existing computational approaches predominantly f... read more
OBJECTIVES: Female-specific cancers, including breast, ovarian, cervical and uterine malignancies, lack comprehensive early detection approaches, particularly for ovarian and endometrial cancers where effective population-level screening remains limi... read more
INTRODUCTION: Pulmonary embolism (PE) is a potentially fatal condition requiring timely diagnosis and treatment. CT pulmonary angiography (CTPA) is the gold standard for diagnosis and indicates PE severity through radiological markers of right heart ... read more
OBJECTIVES: To develop a machine learning (ML)-based risk prediction model for 1-year mortality in ST-elevation myocardial infarction (STEMI) patients undergoing primary or rescue percutaneous coronary intervention. DESIGN: Patient data, including de... read more
INTRODUCTION: High costs of screening and diagnostic tests remain a major barrier to timely tuberculosis (TB) identification in resource-limited settings. Evidence on the cost-effectiveness of scalable screening algorithms is limited. Start4All is a ... read more
BACKGROUND: Combination immune checkpoint inhibitors are recommended as first-line therapy for advanced hepatocellular carcinoma. However, only a third of patients respond to treatment, and improved approaches to predict response are required. Using ... read more
Digital pathology is a major technological revolution for pathology. It modernizes routine practices and paves the way for the integration of artificial intelligence (AI) solutions for diagnostic and research purposes. At Rennes University Hospital, ... read more
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