AI Medical Compendium

Machine Learning-Guided Engineering of Protein Phase Separation Properties in Immune Regulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Feb 11, 2026

Phase separation (PS) underpins compartmentalization in living cells, facilitating the formation of membraneless organelles and the regulation of cellular processes. Despite the increasingly pivotal role of engineering protein PS properties in the st... read more

Computational Evolution of Anti-PD-1 Antibodies Induces Structural Refolding for High-Affinity Interactions.

Biochemistry Feb 11, 2026

Checkpoint inhibitors targeting the PD-1/PD-L1 axis are key immunotherapies, but the dynamic and flexible nature of PD-1 complicates rational antibody engineering. Here, we use computational saturation mutagenesis, AlphaFold prediction, and molecular... read more

Physician Perspectives on Web-Based Real-World Statistics for Better-Informed Drug Selection in Epilepsy: Mixed Methods Study.

JMIR formative research Feb 11, 2026

BACKGROUND: Lately, big data studies have shown promise in using patient characteristics to rank the likelihood of retention of antiseizure medications (ASMs), a measure indicating tolerability as well as effect. How such results can be integrated in... read more

Workload Intensity in Human-Robot Collaboration: A Personalized Approach to Sustainable Efficiency and Well-Being.

Human factors Feb 11, 2026

ObjectiveTo investigate how varying workload intensity and personalized conditions influence physiological stress responses and task efficiency in human-robot collaboration (HRC).BackgroundHRC is increasingly used to enhance productivity and reduce p... read more

Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Feb 11, 2026

PURPOSE: Predictive biomarkers to guide selection of first-line chemotherapy for advanced pancreatic ductal adenocarcinoma (PDAC) are an unmet clinical need. This study used the Computational Histology Artificial Intelligence (CHAI) platform to devel... read more

Impact of AI Scribes on Physician Productivity and Workflow in Medical Oncology.

JCO oncology practice Feb 11, 2026

PURPOSE: Artificial intelligence (AI) scribes are being rapidly adopted in oncology, yet their real-world impact on physician productivity, workflow, and workplace satisfaction is understudied. We evaluated the quantitative and qualitative effects of... read more

Reconfigurable Floating Gate Memristors for High-Accuracy Neuromorphic Computing.

ACS applied materials & interfaces Feb 11, 2026

The explosive growth of computational data poses significant challenges to conventional von Neumann architectures and network processing capabilities. Two-dimensional floating gate memristors, with their compact footprint, high storage density, prolo... read more

Computerized Self-Reported Medical History Taking to Support Early Rule Out of Major Adverse Cardiac Events in Patients With Acute Chest Pain: Post Hoc Analysis of the CLEOS-CPDS Prospective Cohort Study.

Journal of medical Internet research Feb 11, 2026

BACKGROUND: Self-reported, computerized history taking (CHT) may enable efficient collection of medical histories for acute chest pain management. OBJECTIVE: The primary aim is to determine the diagnostic performance of 4 CHT-derived chest pain risk ... read more

Text-Based Depression Estimation Using Machine Learning With Standard Labels: Systematic Review and Meta-Analysis.

Journal of medical Internet research Feb 11, 2026

BACKGROUND: Depression affects people's daily lives and even leads to suicidal behavior. Text-based depression estimation using natural language processing has emerged as a feasible approach for early mental health screening. However, most existing r... read more

Selective multimodal deep learning for reliable breast cancer subtype classification from histopathology and genomic data.

Medical engineering & physics Feb 11, 2026

Accurate classification of breast cancer subtypes is critical for personalized treatment planning and prognostic assessment. While histopathology and RNA-seq data each provide complementary insights into tumor biology, their integration remai... read more

Artificial Intelligence Medical Compendium