Protein sequence determines structure, function, and dynamics, yet the gap between sequenced proteins and experimentally determined structures continues to widen. While machine learning approaches like AlphaFold2 have transformed structural biology, ... read more
Journal of chemical information and modeling
Feb 10, 2026
Advances in artificial intelligence and deep generative models have enabled the rapid generation of novel molecular structures for advanced material science and drug discovery. However, the effective evaluation of these candidates still depends, in t... read more
BACKGROUND AND AIMS: In patients with sepsis, anticoagulant therapy is expected to have maximal efficacy when administered before the development of sepsis-induced overt disseminated intravascular coagulation (DIC). This therapeutic strategy requires... read more
Large language models (LLMs) are increasingly used by patients and families to interpret complex medical documentation, yet most evaluations focus only on clinician-judged accuracy. In this study, 50 pediatric cardiac intensive care unit notes were s... read more
OBJECTIVES: To examine the emotional, cognitive and dispositional experience of children and adolescents undergoing Lokomat rehabilitation by integrating self-evaluation, therapist observations and physiological metrics across repeated sessions, with... read more
OBJECTIVE: To expose reasoning pathways of a reinforcement learning policy for Medicaid care coordination, develop an error taxonomy and implement fairness-aware guardrails. DESIGN: Retrospective interpretability audit using attention analysis, Shapl... read more
OBJECTIVE: To develop a pragmatic model to predict total knee replacement (TKR) in knee osteoarthritis using non-imaging clinical, genetic and lifestyle data with machine learning (ML)-guided feature selection. METHODS: We analysed 3790 Osteoarthriti... read more
AJNR. American journal of neuroradiology
Feb 10, 2026
OBJECTIVES: 7T MRI enhances lesion detection in epilepsy but is limited by radiofrequency transmission field (B1+) inhomogeneity and long scan times. Recent advancements in dynamic parallel transmission and deep-learning-based reconstructions offer p... read more
BACKGROUND: Spree Bar, a line of e-cigarette devices introduced in 2023, leverages 6-methylnicotine (6-MN) as its primary ingredient and is available in nine flavours, each represented by artificial intelligence (AI)-generated avatars. AIMS: To chara... read more
BACKGROUND: Length of hospital admission after major oncologic surgery is often highly variable. Although in carefully selected patients, early discharge can be safe, few automated systems exist to prospectively identify eligible patients. We aimed t... read more
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