AI Medical Compendium

Predicting total knee replacement in knee osteoarthritis using a machine learning-guided approach in patients of the Osteoarthritis Initiative (OAI).

RMD open Feb 10, 2026

OBJECTIVE: To develop a pragmatic model to predict total knee replacement (TKR) in knee osteoarthritis using non-imaging clinical, genetic and lifestyle data with machine learning (ML)-guided feature selection. METHODS: We analysed 3790 Osteoarthriti... read more

Mechanistic interpretability of reinforcement learning in Medicaid care coordination.

BMJ health & care informatics Feb 10, 2026

OBJECTIVE: To expose reasoning pathways of a reinforcement learning policy for Medicaid care coordination, develop an error taxonomy and implement fairness-aware guardrails. DESIGN: Retrospective interpretability audit using attention analysis, Shapl... read more

Understanding patient experience during Lokomat rehabilitation in children and adolescents: a clinical observational study combining self-evaluation and physiological metrics.

BMJ open Feb 10, 2026

OBJECTIVES: To examine the emotional, cognitive and dispositional experience of children and adolescents undergoing Lokomat rehabilitation by integrating self-evaluation, therapist observations and physiological metrics across repeated sessions, with... read more

Evaluating Large Language Model-Generated Clinical Summaries Through a Dual-Perspective Framework: Retrospective Observational Study.

JMIR AI Feb 10, 2026

Large language models (LLMs) are increasingly used by patients and families to interpret complex medical documentation, yet most evaluations focus only on clinician-judged accuracy. In this study, 50 pediatric cardiac intensive care unit notes were s... read more

Practical machine learning model for early and accurate prediction of disseminated intravascular coagulation before its progression to an overt stage.

Thrombosis and haemostasis Feb 10, 2026

BACKGROUND AND AIMS: In patients with sepsis, anticoagulant therapy is expected to have maximal efficacy when administered before the development of sepsis-induced overt disseminated intravascular coagulation (DIC). This therapeutic strategy requires... read more

MolVE: An Open-Source Web Platform for Visualizing and Evaluating AI-Designed Molecules to Aid in Prioritization.

Journal of chemical information and modeling Feb 10, 2026

Advances in artificial intelligence and deep generative models have enabled the rapid generation of novel molecular structures for advanced material science and drug discovery. However, the effective evaluation of these candidates still depends, in t... read more

Rapid and interpretable protein contact map prediction using a pattern-matching strategy.

Physical biology Feb 10, 2026

Protein sequence determines structure, function, and dynamics, yet the gap between sequenced proteins and experimentally determined structures continues to widen. While machine learning approaches like AlphaFold2 have transformed structural biology, ... read more

EEG foundation models: A critical review of current progress and future directions.

Journal of neural engineering Feb 10, 2026

PREMISE: Patterns of electrical brain activity recorded via electroencephalography (EEG) offer immense value for scientific and clinical investigations. The inability of supervised EEG encoders to learn robust EEG patterns and their over-reliance on ... read more

Drug Repositioning by Belief Networks and Ensemble Method.

Biomedical physics & engineering express Feb 10, 2026

The approach of drug repositioning, recognized as an efficient strategy to reduce costs and shorten development timelines in the pharmaceutical industry, has garnered significant interest among researchers. With vast datasets rich in valuable insight... read more

Digitized Canine Olfaction and Multimodal Biosensing for Breath-Based Multi-Cancer Detection: A Hypothesis-Driven Perspective.

Journal of breath research Feb 10, 2026

Multi-Cancer Early Detection (MCED) is critical for reducing cancer mortality, however current screening technologies have limitations in accessibility, cost, and early stage sensitivity. Breath-based detection using volatile organic compounds (VOCs)... read more

Artificial Intelligence Medical Compendium