Nanoparticles traverse the blood-brain barrier (BBB) through passive diffusion and vesicular transcytosis, but the quantitative contributions of these routes remain difficult to determine. Here, we combine a controlled in-vitro human BBB model (hCMEC... read more
Although enzymatic retrosynthesis planning is widely used to accelerate drug synthesis and discovery, it still faces key challenges, including limited knowledge transfer from general chemical space and incomplete EC number prediction. Here, we introd... read more
BACKGROUND: Predicting drug-protein interactions (DPI) is essential for effective and safe drug discovery. Although deep learning methods have been extensively applied to DPI prediction, effectively leveraging the multi-structural and multimodal data... read more
The paramount challenge in precision oncology lies in further improving quality of life and response rates for individual patients. Efforts toward these goals are steadily expanding the scope of clinical implementation, despite ongoing challenges suc... read more
We propose that word embeddings of atoms derived from scientific literature are revisited as autonomous machine learning predictors in materials design. If static word embeddings encode comprehensive physicochemical information, joined embeddings of ... read more
BMC medical informatics and decision making
Feb 9, 2026
BACKGROUND: Cytomegalovirus (CMV) End-Organ Disease (EOD) remains a significant complication in immunocompromised individuals, particularly transplant recipients and patients undergoing chemotherapy. Accurate prediction of CMV EOD is essential for ti... read more
BACKGROUND: Zoonotic diseases pose a major threat to both human and animal health, contributing significantly to global morbidity and mortality. Accurate diagnosis is crucial for effective control and treatment, with microscopic examination serving a... read more
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