Background: Identifying early brain-based markers of cognitive decline is critical for preventive strategies in Alzheimer's disease. Individuals with a familial risk may exhibit subtle functional brain changes years before clinical symptoms emerge. T... read more
Histone modifications underpin the cell-type-specific gene regulatory networks that drive the remarkable cellular heterogeneity of the adult mammalian brain. Here, we profiled four histone modifications jointly with transcriptome in 2.5 million nucle... read more
The electrocardiogram (ECG) is a critical tool in the diagnosis and monitoring of cardiovascular disease. Although traditional 12-lead ECGs offer comprehensive insights into the electrical activity of the heart, they typically require clinical settin... read more
Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer mortality. While early detection improves outcomes, current non-invasive tests often lack sensitivity for early-stage CRC and advanced precancerous lesions (APL). Stool-based h... read more
Background: We present BODHI (Balanced, Open-minded, Diagnostic, Humble, and Inquisitive), an engineering framework for curiosity-driven and humble clinical decision support AI. Despite growing capabilities, large language models (LLMs) often express... read more
Background- Eating timing and regularity represent new contributors to metabolic health, however, the time-based aspect of eating behavior is rarely incorporated into traditional cardiometabolic risk assessment strategies. Objectives- The aim of this... read more
Many proteins' biological functions rely on interconversions between multiple conformations occurring at micro- to millisecond (s-ms) timescales. A lack of standardized, large-scale experimental data has hindered obtaining a more predictive understan... read more
To address challenges in food security, a better understanding of crop performance under varying and changing environmental conditions is required. Plant Time Warping (PTW) is a deep learning model that integrates high-throughput field phenotyping da... read more
Pseudouridine ({Psi}) modifications are the most abundant RNA modifications; however, their distribution and functional significance in bacteria remain largely unexplored compared to eukaryotic systems. In this study, we present the first transcripto... read more
When acquiring a motor skill, learners must practice the skill at a difficulty that is challenging but still manageable to gradually improve their performance. In other words, during training, the learner must experience success as well as failure. D... read more
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