Systemic autoimmune rheumatic diseases (SARDs) are a heterogeneous group of autoimmune conditions characterized by immune system dysregulation leading to chronic inflammation and tissue damage. The overlapping clinical manifestations make differentia... read more
Importance: High-quality discharge summaries are essential for safe care transitions but contribute substantially to clinician documentation burden and burnout. While retrospective studies suggest large language models (LLMs) can generate clinical su... read more
Background The burden of new HIV infections and HIV-related deaths have declined dramatically in sub-Saharan Africa (SSA). However, current HIV surveillance systems are primarily donor-funded and rely on data from population-based surveys and routine... read more
Artificial intelligence (AI) is increasingly positioned as a transformative tool in education and health. Yet empirical evidence on AI readiness in low- and middle-income countries, particularly among youth, remains scarce. This study examined patter... read more
Abstract Objective: To address the inefficiency, subjectivity, and high expertise barrier of traditional epidemiological causal inference, this study designed, developed, and validated an AI-powered agent (EpiCausalX Agent) to automate the end-to-end... read more
Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer's disease (AD), but whether these programs differ between clinical symptoms and neuropathological burden remains unclear. Using single nucleus RNA seq... read more
Background and Purpose Embolic stroke of undetermined source (ESUS) emains a major diagnostic challenge in vascular neurology, as a substantial proportion of patients lack an identifiable embolic source despite standardized diagnostic workup. The fai... read more
Decision-making in drug development spans heterogeneous stages from molecular design to clinical optimization, yet computer-aided workflows across stages remain fragmented, limiting traceability from evidence-derived clinical questions to simulation ... read more
Motivation: Alternative splicing (AS) is a fundamental regulatory mechanism that expands transcriptomic and proteomic diversity by generating multiple mRNA isoforms from a single gene. Aberrant AS has been implicated in numerous diseases through the ... read more
Single-cell expression quantitative trait loci (eQTL) studies hold promise for linking genetic variants to changes in gene expression in individual cells, thereby offering deeper insights into the genetic basis of human traits and diseases. Existing ... read more
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