AI Medical Compendium

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups

bioRxiv Jun 3, 2026

T-cell acute lymphoblastic leukemia (T-ALL) comprises molecularly diverse subtypes, but robust cross-cohort validations and operational gene-expression definitions are lacking. To establish a gene-expression-anchored framework for T-ALL subtyping, we... read more

bioinformatics

Deep learning insights into β-lactamase dynamics and resistance evolution.

The Biochemical journal Jun 3, 2026

The rapid global expansion of β-lactamase-mediated antimicrobial resistance demands mechanistic approaches capable of resolving the dynamics of enzyme adaptation. Although β-lactamase evolution often involves subtle rearrangements rather than large s... read more

Synthesis of Amyloid Images Using a Generative Adversarial Network from 2-Dimensional 18F-FDG Images and Evaluation for Clinical Use.

Journal of nuclear medicine technology Jun 3, 2026

The use of amyloid PET to assess patient suitability of disease-modifying drugs for Alzheimer disease is increasing. This study aimed to synthesize amyloid PET images from 18F-FDG PET images using a generative artificial intelligence algorithm to red... read more

Profiling cognition and brain metabolism in amyotrophic lateral sclerosis and frontotemporal dementia.

Brain : a journal of neurology Jun 3, 2026

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are described as a disease continuum, given their shared clinical, genetic and pathological characteristics. Comparisons of clinical and biomarker features within the ALS and behav... read more

Constructing targeted minimum loss/maximum likelihood estimators: a simple illustration to build intuition.

American journal of epidemiology Jun 3, 2026

Machine learning is increasingly used to estimate nuisance functions in causal inference. The efficient influence function (EIF) offers a principled way to construct estimators that can incorporate machine learning with valid inference (eg, estimate ... read more

Long-term exposure to wildfire smoke particulate matter and incident stroke: a US nationwide study.

European heart journal Jun 2, 2026

BACKGROUND AND AIMS: Wildfire smoke is a growing public health concern, particularly due to its high fine particulate matter (PM2.5) concentrations. While short-term exposure has been linked to adverse cardiovascular outcomes, long-term effects remai... read more

Detecting inflammatory arthritis in hand smartphone photographs: development and validation of a computer vision model in clinical settings.

Rheumatology (Oxford, England) Jun 2, 2026

OBJECTIVE: Computer vision can classify inflammatory arthritis on smartphone photographs. We aimed to train, validate and judiciously choose a model for detecting hand synovitis from standardized smartphone photographs in a real-world rheumatology ou... read more

Advances in body composition imaging for diagnosis and monitoring: From radiologic assessment to precision medicine.

Journal of the Chinese Medical Association : JCMA Jun 2, 2026

Body composition (BC) is a key determinant of metabolic risk, treatment tolerance, and long-term outcomes. The distribution of skeletal muscle, visceral adipose tissue (VAT), and ectopic fat provides greater prognostic information than total body wei... read more

Rethinking cognitive recalibration: Integrating AI into the management of affordances across the life-stages.

The Behavioral and brain sciences Jun 2, 2026

This paper integrates artificial intelligence into affordance management to quantify and simulate perceived opportunities and threats across the life course. Using computer vision, reinforcement learning, and digital twins, we outline methods to capt... read more

Autogenic transitions in individuality.

Comptes rendus biologies Jun 2, 2026

Major evolutionary transitions in individuality occur when previously independent entities become components of a new unit whose parts share a reproductive fate. Most discussions focus on transitions arising through the integration of independent lin... read more

Artificial Intelligence Medical Compendium