BACKGROUND: Protein biologics are indispensable in disease prevention, diagnosis, and therapy, yet their development remains largely constrained by reliance on native protein scaffolds, resulting in long development timelines, limited structural and ... read more
Variants of uncertain significance (VUS) in genes implicated in thoracic aortic aneurysm (TAA) present clinical challenges due to ambiguous pathogenicity and low patient representation. This study investigates the pathogenic potential of missense VUS... read more
BACKGROUND: The lactate-to-albumin ratio (LAR) is correlated with mortality in critically ill patients; however, its predictive value for sepsis in the elderly remains underexplored. METHODS: This retrospective cohort study used the data from the MIM... read more
BACKGROUND: Diabetic kidney disease (DKD) represents the leading cause of end-stage renal disease (ESRD) worldwide, characterized by a complex pathophysiology and heterogeneous progression. Accurate prediction of the onset, progression, and adverse o... read more
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