Immunohistochemistry (IHC) provides information on protein expression in tissue sections and is commonly used to support pathology diagnosis and disease triage. While AI models for H\&E-stained slides show promise, their applicability to IHC is limit... read more
Large language models (LLMs) have achieved remarkable capabilities, yet methods to verify which model components are truly necessary for language function remain limited. Current interpretability approaches rely on internal metrics and lack external ... read more
Identifying and making statistical inferences on differential treatment effects (commonly known as subgroup analysis in clinical research) is central to precision health. Subgroup analysis allows practitioners to pinpoint populations for whom a treat... read more
Sepsis is a major public health concern due to its high morbidity, mortality, and cost. Its clinical outcome can be substantially improved through early detection and timely intervention. By leveraging publicly available datasets, machine learning (M... read more
Clustered data, which arise when observations are nested within groups, are incredibly common in clinical, education, and social science research. Traditionally, a linear mixed model, which includes random effects to account for within-group correlat... read more
Synthetic data, an appealing alternative to extensive expert-annotated data for medical image segmentation, consistently fails to improve segmentation performance despite its visual realism. The reason being that synthetic and real medical images exi... read more
Medical audio classification remains challenging due to low signal-to-noise ratios, subtle discriminative features, and substantial intra-class variability, often compounded by class imbalance and limited training data. Synthetic data augmentation ha... read more
Temporal comparison of chest X-rays is fundamental to clinical radiology, enabling detection of disease progression, treatment response, and new findings. While vision-language models have advanced single-image report generation and visual grounding,... read more
Infrared small targets are typically tiny and locally salient, which belong to high-frequency components (HFCs) in images. Single-frame infrared small target (SIRST) detection is challenging, since there are many HFCs along with targets, such as brig... read more
Large vision-language models such as CLIP struggle with long captions because they align images and texts as undifferentiated wholes. Fine-grained vision-language understanding requires hierarchical semantics capturing both global context and localiz... read more
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