Abstract Objective More people than ever before are living with cancer. Patient education is a core component of cancer care, and patients are increasingly using large language models (LLMs), such as ChatGPT, for advice. The objectives of this study ... read more
Purpose: Large language models (LLMs) can classify biomedical documents accurately, but strong performance does not prove they are using the supplied text rather than identifier-triggered parametric knowledge. We tested whether oncology trial-success... read more
Background: Prognostic assessment in critically ill patients with cancer remains challenging, as conventional ICU severity scores often perform suboptimally in this population. Machine learning (ML) approaches may improve outcome prediction by integr... read more
Background: Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal mesenchymal tumor, driven by tyrosine-protein kinase KIT and platelet-derived growth factor receptor A (PDGFRA) mutations. Specific variants, such as KIT exon 11 de... read more
Abstract Purpose: To quantify run-to-run reproducibility of Gemini 3 Flash Preview and GPT-5.2 for biomedical trial-success classification across temperature and reasoning/thinking settings, and to assess whether single-run reporting is sufficient. M... read more
Chronic kidney disease (CKD) affects nearly 850 million individuals globally; the prevalence of undiagnosed CKD is 60%. Taking advantage of the relationship between CKD and cardiovascular disease, we developed a deep learning (DL) model to detect CKD... read more
High-quality bioinformatics plotting is important for biology research, especially when preparing for publications. However, the long learning curve and complex coding environment configuration often appear as inevitable costs towards the creation of... read more
Summary: Ghost introgression is a challenging problem in population genetics. Recent studies have explored supervised learning models, namely logistic regression and UNet++, to detect genomic footprints of ghost introgression. However, their applicab... read more
ALS shows marked clinical heterogeneity, yet much real-world evidence remains trapped in unstructured reports. Here we introduce MEDSTREM, a large-language-model (LLM)-based agent that converts patient-sourced document images into standardized longit... read more
Dexterous grasping requires the seamless integration of proprioceptive feedback with predictive motor commands. Yet, how cortical circuits combine afferent feedback with efference copies to support skilled hand control remains poorly understood. Here... read more
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