INTRODUCTION: Targeted Muscle Reinnervation (TMR) can prevent and treat neuropathic pain in amputees, but the degree of success varies. This study developed a Machine Learning (ML) model to predict the likelihood of sustained pain mitigation followin... read more
Links between the eye and the central nervous system (CNS) have been recognized since the origins of the ophthalmoscope. Owing to the elegant topography of the afferent visual pathway and its close embryonic, anatomical, and physiological connections... read more
Journal of chemical information and modeling
Feb 2, 2026
Exploring potential microbe-drug associations (MDAs) not only facilitates drug discovery and clinical treatment but also contributes to a deeper understanding of microbial mechanisms. However, most MDA discoveries rely on biological experiments, whic... read more
INTRODUCTION: Within the UK there are 33 deaths every day from prostate cancer, second only to lung cancer as the most common cause of cancer death in males in the UK. Of the 55ā000 new cases each year, up to 50% of these patients will receive radiot... read more
OBJECTIVES: To develop and validate a tool for standardised quality assessment of data-driven algorithms in healthcare, focusing on the underlying data pipeline. METHODS: Data Assessment Tool for Algorithm Critical Appraisal and Robust Evidence (DATA... read more
Enzymes are highly efficient biocatalysts known for their chemical, regio-, and stereoselectivity, making them valuable in industrial applications. While directed evolution has expanded the scope of enzyme-catalyzed reactions, the range of enzymatic ... read more
Artificial intelligence (AI) is transforming healthcare, with large language models emerging as important tools for clinical practice, education, and research. To use it safely and effectively, healthcare professionals need to understand how it works... read more
BACKGROUND: Early graft failure within 90 postoperative days is the leading cause of mortality after heart transplantation. Existing risk scores, based on linear regression, often struggle to capture the complex, multifactorial biological interaction... read more
OBJECTIVES: Urbanization-related air pollution may be associated with olfactory dysfunction (OD) in China, yet population studies are lacking. METHODS: We conducted a cross-sectional study of 1500 participants in urbanizing Yancheng, China (2023-2025... read more
Nonsuicidal self-injury (NSSI) in youth is clinically heterogeneous. We aimed to identify distinct psychopathology-based profiles among children and adolescents reporting NSSI and their longitudinal correlates. Participants (Nā=ā1 345) were drawn fro... read more
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