AI Medical Compendium

Computational methods for signal peptide prediction: From statistical models to deep learning.

Biotechnology advances Jan 31, 2026

Signal peptides are short amino acid sequences located at the N-terminus of proteins. They guide newly synthesized proteins to their correct cellular destinations, playing a crucial role in protein localization and transport. Traditional experimental... read more

Disulfidptosis in osteoarthritis: Role of SLC2A3 downregulation and potential therapeutic implications.

Experimental gerontology Jan 31, 2026

OBJECTIVE: Disulfidptosis is a newly recognized form of regulated cell death characterized by actin cytoskeleton collapse under disulfide stress. Recent studies suggest it may significantly contribute to osteoarthritis (OA), though its exact role in ... read more

Uncovering treatment effect heterogeneity in pragmatic gerontology trials.

Experimental gerontology Jan 31, 2026

Detecting heterogeneity in treatment response enriches the interpretation of gerontologic trials. In aging research, estimating the intervention's effect on clinically meaningful outcomes poses analytical challenges when outcomes are truncated by dea... read more

Comparison of manual with artificial intelligence-aided interpretation of ANA HEp-2 IIF assay patterns in a clinical diagnostics lab.

Clinica chimica acta; international journal of clinical chemistry Jan 31, 2026

OBJECTIVES: Detection of antinuclear antibody (ANA) via indirect immunofluorescence (IIF) on HEp-2 cells is a screening test for the serological diagnosis of systemic autoimmune rheumatic diseases. Automated interpretation of ANA classification by no... read more

Multisite derivation of a machine learning algorithm using high sensitivity troponin to predict major adverse cardiac events in the emergency department.

International journal of cardiology Jan 31, 2026

OBJECTIVE: To develop a machine learning (ML) algorithm to stratify risk for major adverse cardiac events (MACE) within 30 days in emergency department (ED) patients undergoing troponin testing. DESIGN: Retrospective cohort analysis using extreme gra... read more

Evaluation of large language models as decision support tools for head and neck cancer management: A blinded multidisciplinary simulation study.

Oral oncology Jan 31, 2026

BACKGROUND: The management of head and neck cancer relies on multidisciplinary expertise; however, access to tumor boards remains variable. Large language models (LLMs) may support guideline-based decision-making, although performance in complex onco... read more

Ensemble-based mapping and trophic characterization of lentic water bodies in the Middle Ganga Basin under climate and land use change.

Journal of environmental management Jan 31, 2026

Lentic small water bodies (LSWBs), such as ponds and small lakes, play an important role in freshwater ecosystems by supporting biodiversity, groundwater recharge, and rural subsistence. However, their size and ecological integrity are being impacted... read more

Divergent key driving factors of soil salinity in Tarim River Basin, Northwest China.

Journal of environmental management Jan 31, 2026

Soil salinization threatens agricultural sustainability and economic welfare, challenging global food production and sustainable agricultural development. Understanding the interactions between soil salinity and covariates is essential for advancing ... read more

Implementation and current status of frailty assessment in Japanese hospitals: Processes, epidemiology, and future directions.

Bioscience trends Jan 31, 2026

Frailty has become a pressing health concern in Japan as it has entered a super-aged society. Early identification of frailty is essential to preventing disability, hospitalization, and dependency on long-term care, and yet the implementation of stan... read more

OMOM SmartScan provides noninferior assessment of Lewis score and CECDAI in Crohn's disease vs full-video review.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Jan 31, 2026

BACKGROUND: Small bowel capsule endoscopy (SBCE) is central to Crohn's Disease (CD) care but limited by lengthy review and reader variability. We tested whether an artificial-intelligence (AI)-triaged, human-reviewed workflow - SmartScan, SS - can se... read more

Artificial Intelligence Medical Compendium