Alternative polyadenylation (APA) is a pervasive RNA-processing mechanism in eukaryotes that significantly promotes transcriptome and proteome diversity. Here we proposed PolyAseqTrap, an R package for probing polyA sites from diverse 3' sequencing d... read more
Annals of clinical and translational neurology
Jan 31, 2026
OBJECTIVE: Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)-delivered therapeutic... read more
Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae (pneumococcus) colonization could enable development of serotype-independent vaccines. In our controlled human infection model, no individual IgG or c... read more
Clinical biomechanics (Bristol, Avon)
Jan 31, 2026
BACKGROUND: Motion analysis plays an important role in clinical decision-making and biomechanical research. Conventional assessments rely on laboratory-based motion capture and force plates, which are accurate but resource-intensive. Wearable sensors... read more
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Jan 31, 2026
BACKGROUND: Metallothioneins (MTs) are crucial metal-binding proteins involved in cellular zinc homeostasis and oxidative stress response. However, the role of metallothionein-related genes (MRGs) in breast cancer (BC) pathogenesis and their potentia... read more
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