How informative are preschoolers' speech vocalizations? Preschoolers' speech is often imprecise, highly variable and hard to interpret by humans and machines; consequently, its predictive value for later developmental outcomes remains quite underexpl... read more
Protein conformational dynamics and ligand binding processes are fundamental to biological function, yet their systematic sampling and thermodynamic characterization remain challenging. Here, we present a distance-restraint-guided inference method th... read more
Dopamine (DA) has been implicated in exploration-exploitation behaviour, i.e., exploring novel, potentiallybetter options vs. exploiting known, previously rewarding options. Impairments in this trade-off occur inpsychiatric disorders involving DAergi... read more
Cyclic peptides are a promising class of therapeutics due to their attractive drug qualities such as increased structural stability, cell permeability, and resistance to proteolytic degradation. With recent advancements in cyclic peptide backbone gen... read more
Motivation: Extracting knowledge from biomedical data is crucial for advancing our understanding of biological systems and developing novel therapeutics. The quantity, quality, and resolution of biomedical data constantly evolves, requiring the autom... read more
Background: Accurate discrimination of true structural variants (SVs) from artifacts in long-read sequencing data remains a critical bottleneck. Numerous machine learning solutions have been proposed, ranging from classical models using engineered fe... read more
Weeds present a major challenge to agricultural productivity, competing with crops for critical resources like water, nutrients, and sunlight, resulting in significant yield reductions. Prompt weed identification is essential for enabling effective c... read more
Clearing Assisted Scattering Tomography (CAST) extends coherent scattering tomography to whole-brain imaging, enabling visualization of fine-scale brain-wide connectivity. As a coherent optical tomography modality, CAST is inherently affected by spec... read more
This research provides an XAI-driven genetic profiling approach that may contribute to scientific discoveries in genetic research. We propose a new explainable AI (XAI) classification algorithm that combines probabilistic circuits with the Nucleotide... read more
Background: Childhood T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with poor prognosis. Differently from B-cell precursor ALL, T-ALL lacks effective risk stratification strategies. A recent study has integrat... read more
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