AI Medical Compendium

Digital twins in oncology: From predictive modelling to personalised treatment strategies.

Critical reviews in oncology/hematology Jan 30, 2026

The digital twin (DT) concept, originating from engineering disciplines, has emerged as a transformative technology in healthcare, particularly in oncology. A digital twin creates a dynamic, virtual replica of a patient's physiological and pathologic... read more

Risk of malignancies and all-cause mortality in patients with pemphigus: A longitudinal cohort study.

Journal of the American Academy of Dermatology Jan 30, 2026

Emerging roles of artificial intelligence/machine learning (AI/ML) towards new understandings in molecular crosstalk between circRNA-CUL3-TKI to resensitize chemoresistant cancers.

Molecular and cellular probes Jan 30, 2026

Cancer arises and is resistant to therapy via intricate molecular networks that are poorly characterised. While individually, Cullin-3 (CUL3) and circular RNAs (circRNAs) have been reported to modulate cancer, their synergistic effect in the modulati... read more

Changing the container closure system of lyophilized products: Real or perceived risk to process efficiency and product quality?

Journal of pharmaceutical sciences Jan 30, 2026

The container-closure system (CCS), specifically the glass vial, plays a pivotal role in heat transfer during lyophilization, thereby influencing process efficiency and product quality. Therefore, a change in CCS without corresponding changes in the ... read more

Synthetic data in the clinical laboratory: methods, applications, and future prospects.

Clinica chimica acta; international journal of clinical chemistry Jan 30, 2026

Clinical laboratories face stringent privacy constraints, limited datasets for rare conditions, and rising demands to validate AI algorithms and workflows safely. Synthetic data-artificially generated data that preserve the statistical characteristic... read more

Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.

APL bioengineering Jan 30, 2026

Atherosclerosis (AS), a chronic inflammatory process driven largely by macrophage-mediated plaque formation, remains poorly understood in mitochondrial-macrophage crosstalk. While CYBA polymorphisms correlate with cardiovascular risk, the functional ... read more

A novel explainable deep-learning approach for network analysis of epistatic interactions.

NAR genomics and bioinformatics Jan 30, 2026

Epistatic interactions of gene loci often determine complex trait phenotypes and may indicate the underlying molecular mechanisms of traits and diseases. Yet, the inference of epistatic interactions and gene-gene networks remains challenging. Neural ... read more

Mechanistic insights and catalyst design for the selective hydrogenolysis of cellulose to C2-C3 alcohols.

Chemical science Jan 30, 2026

Catalytic hydrogenolysis of cellulose into low-carbon alcohols offers a promising route toward sustainable chemical manufacture and carbon-neutral energy systems. Recent advances in aqueous-phase catalysis have progressively clarified the reaction ne... read more

Evaluating ChatGPT-5.0 in developmental dysplasia of the hip: A scenario-based validation study against AAOS and AAP guidelines.

Journal of children's orthopaedics Jan 30, 2026

PURPOSE: Developmental dysplasia of the hip (DDH) requires timely, guideline-concordant decisions to prevent long-term morbidity. ChatGPT-5.0 may support clinicians-especially where pediatric orthopedic expertise is limited, but their reliability acr... read more

The Emerging Role of Olfactory Receptors: From Genomics to Precision Medicine.

Molecular diagnosis & therapy Jan 30, 2026

Olfactory receptors (ORs), once considered peripheral to sensory biology, are now recognized as functionally important components of precision medicine. This review synthesizes genomic, structural, and translational evidence demonstrating that ORs ac... read more

Artificial Intelligence Medical Compendium