AI Medical Compendium

Generative AI in simulation debriefings: an exploratory study using the Team-FIRST framework and qualitative feedback from simulation experts and learners.

Advances in simulation (London, England) Jan 29, 2026

BACKGROUND: Effective debriefings in simulation-based education require accurate observation of team interactions, yet facilitators face challenges due to cognitive load, observer bias, and the complexity of team dynamics. Generative artificial intel... read more

Evaluating the methodological suitability of partial dependence plots and Shapley additive explanations for population-level interpretation of machine learning models in total joint arthroplasty.

Arthroplasty (London, England) Jan 29, 2026

BACKGROUND: Total joint arthroplasty (TJA) complications necessitate the development of accurate risk prediction models; however, interpretability in machine learning remains a challenge. While Shapley Additive Explanations (SHAP) offers insights at ... read more

Ultrasound-Based Kidney Stone Classification Using Kronecker Self-Organizing Map Forward Harmonic Network.

Ultrasonic imaging Jan 29, 2026

Kidney stone disease is a prevalent urological disorder that can result in severe pain, obstruction, and long-term complications if not detected and managed promptly. Traditional diagnostic approaches, particularly those relying on manual assessment ... read more

Hemoglobin as a Molecular Glue: Toward Potent Inhibition of HbS Polymerization in Sickle Cell Disease.

Advanced healthcare materials Jan 29, 2026

Sickle cell disease (SCD), a monogenic disorder arising from a single point mutation in the β-globin gene, continues to pose a significant global health burden despite advances in supportive care. This mutation drives the formation of hemoglobin S (H... read more

Highly efficient and durable Th1-biased protective immunity from a novel mRNA vaccine against RSV via AI-assisted antigen screening.

Molecular therapy : the journal of the American Society of Gene Therapy Jan 29, 2026

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness, imposing a significant burden on global health and society. Here, we report a novel mRNA vaccine that can offer potent and enduring protection against RSV. We designe... read more

Enhancing the CO2 Separation Performance of MOFs-Based Membranes: From Strategic Modifications to Computational Insights.

Small methods Jan 29, 2026

Carbon dioxide (CO2) separation and capture technologie have been considered as a viable strategy for mitigating CO2 emissions to reduce the greenhouse effect. Metal organic frameworks (MOFs)-based membrane separation technology has demonstrated to b... read more

Education as a Tool to Navigate Changing Technology in Radiation Oncology.

Seminars in radiation oncology Jan 29, 2026

While technological innovation in radiation therapy (RT) continues to accelerate, safe and equitable adoption of emerging tools is reliant on the readiness of the workforce and the robustness of associated educational frameworks. Early experience wit... read more

When high accuracy misleads: Stability limits of supervised feature importance in QSAR biodegradation.

Chemosphere Jan 29, 2026

Supervised machine learning excels at target prediction but can mischaracterize structure-biodegradability associations when feature importance is treated as ground truth. Using the QSAR Biodegradation dataset (1055 chemicals; 41 descriptors), we com... read more

Generic fitting models learn edge representations from prenatal retinal waves.

Cognition Jan 29, 2026

Orientation selectivity-the representation of oriented edges-is a hallmark of biological vision, shared across mammals, birds, and reptiles. However, the origins of orientation selectivity are unknown. Is orientation selectivity predetermined, with g... read more

From inhibition to regulation: serpins in health and disease.

Biomedical journal Jan 29, 2026

This issue of the Biomedical Journal highlights regulatory mechanisms that shape aging, disease progression, and biological complexity across molecular, cellular, and systems levels. A central theme is plasminogen activator inhibitor-1 (PAI-1) as a m... read more

Artificial Intelligence Medical Compendium