Artificial Intelligence Medical Compendium

Explore the latest research on artificial intelligence and machine learning in medicine.

Showing 57,261 to 57,270 of 227,153 articles

Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays.

Journal of controlled release : official journal of the Controlled Release Society Jan 28, 2026
Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine learning with high-throughput experimentation to systematically optimize olfactory deposition of solid lipid nanoparticl... read more 

The seeds of the future are in the present: A blind exploration of metastable states.

Proceedings of the National Academy of Sciences of the United States of America Jan 28, 2026
In this work, we present a type of molecular dynamics simulation that aims at finding, in a blind way, metastable states. Using only data coming from an initial unbiased simulation, and with the help of an appropriately defined loss function, we comp... read more 

Mapping targetable sites on the human surfaceome for the design of novel binders.

Proceedings of the National Academy of Sciences of the United States of America Jan 28, 2026
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo protein binder design against these cell surface proteins offers a promising yet underexplored strategy fo... read more 

Absence of dehydration due to superionic transition at Earth's core-mantle boundary.

Science advances Jan 28, 2026
The properties and stability of hydrous phases are crucial to unraveling the mysteries of the deep water cycle. Under deep lower mantle conditions, water and hydrous phases transition into a superionic state. However, superionic effect on their stabi... read more 

Evolution of sensory systems underlies the emergence of predatory feeding behaviors in nematodes.

Proceedings of the National Academy of Sciences of the United States of America Jan 28, 2026
Understanding how animal behavior evolves remains a major challenge, with few studies linking genetic changes to differences in neural function and behavior across species. Here, we identify specific sensory adaptations associated with the emergence ... read more 

ML-automated microfluidic circuit design.

Science advances Jan 28, 2026
Microfluidics enable high-precision and cost-effective processing of biological and chemical substances. However, designing and fabricating microfluidic chips typically requires substantial expertise and numerous design iterations, posing considerabl... read more 

One-stop strabismus digital diagnosis via AI-integrated skin-like and wearable "Eyelectronics".

Science advances Jan 28, 2026
Strabismus, affecting ~4% of children, impairs vision and psychosocial health. However, clinical diagnosis requires multiple instruments and stepwise examinations of ocular alignment, extraocular muscle function, and deviation angle. It is limited by... read more 

Development and external validation of a diagnostic model for differentiating major depressive disorder from bipolar disorder.

BMC psychiatry Jan 28, 2026
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Semi-supervised learning in prostate MRI tumor detection approaches fully supervised performance on external validation.

European radiology Jan 28, 2026
OBJECTIVE: To evaluate the diagnostic performance of semi-supervised learning models for aggressive prostate cancer detection on MRI compared to fully supervised models trained with additional expert annotations. MATERIALS AND METHODS: We used 1500 M... read more 

A comprehensive multi-task deep learning model for kidney cancer: histological subtyping, clinical staging, and anatomical complexity grading.

European radiology Jan 28, 2026
OBJECTIVES: To develop and validate a multi-task deep learning (MTDL) model using multiphase contrast-enhanced CT (CECT) for simultaneously assessing histological subtypes, clinical stages, and anatomical complexity grades of solid malignant renal tu... read more 
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