Artificial Intelligence Medical Compendium

Explore the latest research on artificial intelligence and machine learning in medicine.

Showing 57,441 to 57,450 of 227,388 articles

Gene-centered representation of coding and regulatory variation enables outcome prediction

bioRxiv Jan 29, 2026
Integrating coding and regulatory variation into unified, interpretable representations remains a challenge in functional genomics. Current approaches either focus on common variants or analyze individual variants in isolation, missing the cumulative... read more 
genomics

An Advanced Humanized Systemic Lupus Erythematosus Model Enables Parallel Profiling of B Cell-Targeted Therapies

bioRxiv Jan 29, 2026
B cell-targeted therapies represent a transformative frontier for systemic lupus erythematosus (SLE) intervention, yet clinical recommendation of specific treatment is hampered by the challenge to perform head-to-head comparisons of efficacy-toxicity... read more 
immunology

Artemis: Harnessing Knowledge Graphs for Next-Generation Drug Target Prioritization

bioRxiv Jan 29, 2026
Knowledge graphs (KGs) have become an important asset in biomedical research and drug discovery by enabling the structured integration of heterogeneous biological knowledge. When combined with machine learning (ML), KGs support the identification of ... read more 
bioinformatics

Functional In-Context Learning in Genomic Language Models with Nucleotide-Level Supervision and Genome Compression

bioRxiv Jan 29, 2026
Genomic foundation models aim to learn general-purpose representations directly from DNA sequence, enabling sequence understanding, generation, and probabilistic reasoning across a wide range of biological tasks. Scaling such models to genomic length... read more 
genomics

miRNA-mRNA Interaction Network Analysis in Alzheimer's Disease for Biomarker Discovery

bioRxiv Jan 29, 2026
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by widespread dysregulation of gene expression and regulatory pathways. MicroRNAs (miRNAs) act as key post-transcriptional regulators by modulating messenger RNAs (mRNAs),... read more 
bioinformatics

LSD Reconfigures Cortical Dynamics Through Faster Brain Rhythms and Increased Fractal Dimension

bioRxiv Jan 29, 2026
Lysergic acid diethylamide (LSD) profoundly alters conscious experience, yet the electrophysiological mechanisms by which it reshapes neural dynamics remain incompletely understood. A hallmark of psychedelic states is widespread cortical desynchroniz... read more 
neuroscience

An Artificial Intelligence-based framework for protein interaction design with accelerated KAN-based Positive-Unlabeled learning

bioRxiv Jan 29, 2026
Protein design seeks optimal amino acid sequences for target structures, but designing stable protein complexes remains challenging. We introduce a protein interaction design pipeline combining Monte-Carlo simulation with Metropolis-criteria (MCM) an... read more 
bioinformatics

Machine learning-based image analysis of Parkinson's disease iPS-derived neurons predicts genotype and reveals mitochondria-lysosome abnormalities

bioRxiv Jan 29, 2026
Mitochondrial and lysosomal dysfunction are central features of Parkinson's disease (PD) across major genetic forms including PRKN, SNCA, and LRRK2. We applied cell morphomics, a machine-learning-based framework combining high-content imaging with qu... read more 
neuroscience

Breast cancer radiogenomics analysis via computational perturbation on AI-driven multi-omics guided image synthesis

bioRxiv Jan 29, 2026
Radiogenomics offers a promising non-invasive approach for characterizing breast cancer (BC), yet its progress is often limited by the scarcity of cohorts containing matched imaging and multi-omics data. Recent advances in generative AI have enabled ... read more 
cancer biology

De novo design of a safe and potent respiratory syncytial virus immuno-focusing antigen

bioRxiv Jan 29, 2026
Respiratory syncytial virus (RSV) remains the leading cause of severe respiratory infections in infants, the elderly, and the immunocompromised. Although stabilized full-length pre-fusion (pre-F) protein vaccines are promising, enhanced respiratory d... read more 
microbiology
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