BACKGROUND: Early detection of cardiovascular disease is a global public health priority. Artificial intelligence (AI)-enabled stethoscopes offer robust performance characteristics in point-of-care detection of heart failure, atrial fibrillation, and... read more
PURPOSE OF REVIEW: Lipoprotein(a), Lp(a), is a genetically determined, lifelong risk factor for atherosclerotic cardiovascular disease (ASCVD). Despite broad guideline support for universal one-time testing, Lp(a) measurement remains rare in clinical... read more
Epilepsy is a chronic brain disorder characterized by recurrent seizures resulting from abnormal brain cell activity. The unpredictability of these seizures underscores the criticality of anticipating and promptly addressing them to enhance the patie... read more
INTRODUCTION: High-grade soft tissue sarcomas (STShg) of the extremities are rare cancers with a poor prognosis. Accurate staging at initial evaluation is crucial for determining optimal treatment. Current guidelines recommend systematic chest comput... read more
Handheld ultrasound (HHUS) is indispensable for breast cancer screening but remains compromised by operator-dependent acquisition, subjective 2D interpretation and clock-face annotation. Existing spatial tracking systems for HHUS typically lack integ... read more
Accurate analysis of tumor morphology, vascularity, and tissue stiffness under multimodal ultrasound imaging plays a critical role in the diagnosis of breast cancer. However, manual interpretation across multiple modalities is time-consuming and heav... read more
Wearable microneedles (MNs) biosensors offer significant potential for minimally invasive biomarker detection in interstitial fluid (ISF). However, suboptimal fluid collection efficiency, dermal irritation due to rigid structural components, and inad... read more
Computer methods and programs in biomedicine
Jan 28, 2026
BACKGROUND AND OBJECTIVE: Reliable detection of robust biomarkers from high-dimensional transcriptomic data remains a major challenge in computational oncology. Traditional approaches often suffer from overfitting and poor generalization due to the h... read more
Pogostemon cablin (Blanco) Benth (P.cablin), known for its unique aroma and rich chemical components, occupies an important position in the field of cosmetics, food and medicine. Identifying its origin is crucial for quality control and preventing ad... read more
Current biocompatibility assessment paradigms inadequately predict hemoglobin-material interactions, limiting the rational design of blood-contacting biomedical devices. We developed a hemoglobin sensitivity index (HSI), a predictive mathematical fra... read more
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