Motivation: Modeling inter-omics interactions across multiple molecular levels is critical for deciphering the mechanisms underlying complex diseases. Epigenomic and structural alterations, such as DNA methylation and copy number alterations, modulat... read more
In vectorial embeddings of word meaning, semantic features often reflect consistent directions, or axes, within a representational space. A classic example is gender: the vector spanning boy to girl can be added to the embedding for king to predict q... read more
The Committee on Publication Ethics (COPE) recommends that publishers do not charge for corrections to published papers. Until late 2024 the Journal of Cancer levied a charge on authors (50% of the original article processing charge, APC) for publica... read more
Background Distinguishing individuals with cognitive decline (CD), including early Alzheimers disease, from cognitively normal (CN) individuals is essential for improving diagnostic accuracy and enabling timely intervention. Positron emission tomogra... read more
Glycated hemoglobin (HbA1c) is a central biomarker for long-term glycemic control and diabetes management, traditionally quantified using laboratory-intensive chromatographic or immunochemical assays. As the global burden of diabetes continues to ris... read more
Monkeypox viral disease has been and continues to be a global public health concern. Currently, there are existing, though minimal measures to manage mpox and any future outbreaks. Relying on data-driven modeling for early detection of mpox and predi... read more
Image classification on digital pathology images relies heavily on convolutional neural networks (CNNs), yet the behavior of alternative neural computing paragigms in this domain remains insufficiently characterized. Spiking neural networks (SNNs), w... read more
Background Foundation models have emerged as a promising paradigm for medical imaging AI [7], with claims of improved generalization and reduced bias. However, their robustness to technical acquisition parameters remains unexplored. We evaluated whet... read more
One-third of the world's 70 million people with epilepsy have seizures that are not controlled by medication; and implantable devices are an exciting option for treatment. These devices improve seizure control and can detect impending attacks, missed... read more
BACKGROUND Medical large language models (LLMs) achieving high benchmark accuracy exhibit unexplained variability in clinical tasks, producing errors that clinicians cannot safeguard against. Sparse autoencoders offer a mechanistic interpretability a... read more
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