AI Medical Compendium

Experimental evaluation of AI-driven protein design risks using safe biological proxies

bioRxiv Jan 27, 2026

Advances in machine learning are providing leaps forward for beneficial applications of protein engineering, while also raising concerns about biosecurity. Recently, Wittmann et al. described an in silico pipeline of generative AI tools to reformulat... read more

synthetic biology

A systematic delineation of 3' UTR regulatory elements and their contextual associations

bioRxiv Jan 27, 2026

The 3'UTR encodes regulatory information that shapes transcript abundance and subcellular distribution, yet the underlying sequence rules remain incompletely defined. Using SEERS, we quantified the effects of ~2 million synthetic 3'UTR inserts in A54... read more

genomics

Cervical cancer cell prediction and detection with high test accuracy based on a reliable automated system.

3 Biotech Jan 27, 2026

Cervical cancer ranks as the fourth most prevalent cancer among women worldwide. The increasing incidence and mortality rates are largely attributed to limited screening infrastructure, a shortage of skilled medical personnel, and inadequate awarenes... read more

Bacterial fructan-metabolizing enzymes: modular architecture and biotechnological potential.

3 Biotech Jan 27, 2026

Bacterial fructan-metabolizing enzymes exhibit substantial structural and mechanistic diversity to support their biotechnological uses. Recent findings on glycoside hydrolase (GH) families 32 and 68 emphasize the conserved catalytic triads, calcium-b... read more

The role of artificial intelligence in sarcopenia: Advances, applications, and future directions.

Computational biology and chemistry Jan 27, 2026

Sarcopenia, the gradual loss of skeletal muscle mass, strength, and function, is a growing concern in aging populations. Early detection is vital to reduce the risk of frailty, disability, and mortality, yet traditional diagnostic methods such as ima... read more

Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis.

Colloids and surfaces. B, Biointerfaces Jan 27, 2026

Biological proteins play a crucial role at the intersection of oral health and neuroscience, offering promising opportunities for improved diagnosis, prevention, and treatment. This review highlights the molecular, inflammatory, and biochemical pathw... read more

Role of WNK4 and FKBP5 in asthma: Insights from bioinformatics analysis, machine learning, and preliminary validation.

Biochemical and biophysical research communications Jan 27, 2026

BACKGROUND: The complex and heterogeneous molecular mechanisms of asthma are currently unclear, and treatment outcomes are dismal in some patients. This study aimed to identify biomarkers with diagnostic and therapeutic potential. METHODS: Gene Expre... read more

Stage-wise environmental recovery patterns and cross-domain interactions of planktonic bacterial communities in Zhanjiang Bay following typhoon disturbance.

Environmental research Jan 27, 2026

Typhoon events can abruptly alter local biogeochemical cycles, which may strongly influence microbial community structure and ecological interactions. Climate change is increasing the frequency of extreme weather events such as typhoons, yet the cons... read more

Axial length prediction Model based on screening fundus photography data in school-age children.

Experimental eye research Jan 27, 2026

This study developed deep learning (DL) models to predict axial length (AL) in 6-10-year-old schoolchildren using minimally abnormal color fundus photographs (CFPs), while evaluating the impact of integrating age, Diopter Sphere (DS), and sex. Follow... read more

LocPred-Prok: Prokaryotic protein subcellular localization prediction with a dual-branch architecture and protein language model.

Journal of molecular biology Jan 27, 2026

The precise localization of proteins within prokaryotic cells is fundamental to understanding their function. However, existing models still struggle with challenging localization classes, such as cell wall or outer membrane proteins. We introduce Lo... read more

Artificial Intelligence Medical Compendium