Characterizing the conformational landscapes of G protein-coupled receptors (GPCRs) is fundamental to understanding signal transduction and accelerating rational drug design. However, current computational approaches often rely on static sequence ana... read more
Multivariate analyses of M/EEG data are typically performed on neural responses time-locked to discrete stimulus onsets. Such designs usually reveal high decoding performance during the initial transient response (0-500 ms), which subsequently drops ... read more
Visual working memory is essential for navigating through and interacting with complex real-world environments. It is therefore important to understand how natural visual inputs - characterized by complex contours, continuously varying feature gradie... read more
Deep learning has transformed protein structure prediction and de novo protein design; however, most existing frameworks operate on a single static conformation and underutilize the conformational heterogeneity that governs protein binding and functi... read more
The concept of embodied sensorimotor decision-making proposes that processes implicated in evaluating sensory inputs and selecting appropriate motor actions unfold partly in cortical regions traditionally associated with movement planning and executi... read more
Motivation: One of the challenges encountered when merging heterogeneous observational clinical datasets is the recoding of categorical target variables that may have been measured differently across data sources. Standard machine learning-based appr... read more
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms are recognized: type 1 diabetes (T1D), which involves autoimmune destruction of insulin-producing {... read more
Accurate pose estimation underpins quantitative analysis of behavior, yet many deep learning-based tracking tools remain optimized for offline workflows that rely on fragmented software pipelines, workstation-grade GPUs, or external middleware to ena... read more
Identifying common function-determining structural motifs among proteins with different folds is a foundational task in computational biology with no go-to solution. Indeed, standard alignment tools like TM-align are ill-suited for matching small, se... read more
Neurophysiologists have discovered many mechanisms underlying the production of animal behaviors in specific species; these involve a collection of neuromuscular systems, neuronal membrane and neural network properties, as well as the hormones and ne... read more
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