Background: Accurate determination of genomic biomarkers from tumor sequencing is fundamental to precision oncology, informing disease classification and treatment decisions. In practice, biomarker inference relies on computational pipelines that oft... read more
Autism Spectrum Disorder standardized behavioral assessments provide quantitative measures of symptoms, yet their reliability and consistency have not been systematically evaluated. We present the first large-scale comparative analysis of four widely... read more
Clinical decision-making for multi-morbid patients requires synthesizing evidence from lengthy, fragmented records-a task that exposes the limitations of standard Retrieval-Augmented Generation (RAG) and long-context Large Language Models (LLMs), whi... read more
Background: Delayed or missed diagnosis of congenital heart disease (CHD) contributes to excess pediatric mortality worldwide. Echocardiography (echo) is central to diagnosing and triaging CHD, yet expert interpretation remains a scarce and maldistri... read more
Background: Early diagnosis of dementia can significantly improve care planning and patient outcomes while delaying progression. Machine learning algorithms can identify patterns in clinical and neuroimaging data that may aid in the early detection o... read more
Autism spectrum disorder (ASD) affects a substantial proportion of children worldwide, yet clinical assessment of symptom severity remains resource-intensive and unevenly accessible. Artificial intelligence (AI) has transformative potential to suppor... read more
Comprehending how forces are applied to an object during manipulation can help provide important insights into the quality of behavior in daily tasks. We have developed the Bead Maze Hand Function test to objectively measure the quality of hand funct... read more
Implant-based breast reconstruction is the most common surgical option following mastectomy for breast cancer. Despite its prevalence, up to one-third of patients develop complications within two years. Existing machine-learning models for predicting... read more
Patient selection and enrolment into phase III randomized clinical trials (RCTs) of adjuvant cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor therapies depend on accurate risk definition. However, standard clinicopathologic criteria incompletely ca... read more
Comprehensive clinical history taking is essential for high-quality care. We hypothesized that large language models (LLMs), guided by a structured agentic framework, can efficiently obtain clinically meaningful patient histories. We developed an ite... read more
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