Background: Automated thrombus segmentation on CT imaging could enable routine extraction of clot volume and other biomarkers in large vessel occlusion (LVO) stroke, but current deep learning models provide deterministic masks without indicating when... read more
Objective Accurate and scalable disease phenotyping from electronic health records (EHRs) is foundational for predictive modeling and precision medicine. Traditional rule- and keyword-based approaches are limited by inconsistent documentation and ina... read more
Accurate assessment of patient-ventilator interaction is critical for optimizing respiratory support and detecting harmful dyssynchronies linked to adverse outcomes, including ventilator-induced lung injury and prolonged ICU stays. This requires prec... read more
Quantitative, time-resolved 3D fluorescence microscopy can reveal complex cellular dynamics in living cells and tissues. Broader use remains limited by the difficulty of identifying, segmenting, and tracking objects of different size and shape in cro... read more
Nanopore sequencing has achieved a new standard of accuracy with the advent of R10.4.1 flow cell and high-performance Transformer-based basecalling models. However, existing signal simulators often fail to capture the complex, non-linear dynamics of ... read more
Electric field (EF) stimulation is an emerging neuromodulatory strategy for promoting the repair and functional recovery of degenerated neural networks in neurodegenerative conditions such as glaucoma. EF stimulation therapeutic potential is thought ... read more
Protein-protein interactions (PPIs) and nanobody-antigen interactions (NAIs) play essential roles in cellular function, yet accurate hotspot prediction remains challenging. We present Surf2Spot, a deep learning framework that integrates sequence embe... read more
Sensory neurons modulate organismal physiology and behavior in part by releasing neuropeptides and neurotrophins or growth factors, via the dense core vesicle (DCV) pathway. The precise matching of the sensory input to the identity of released vesicl... read more
Protein function emerges from three-dimensional structure, yet many large-scale protein prediction pipelines still rely solely on linear sequence embeddings. Although multiple structure-aware protein networks have been proposed, they often omit atom-... read more
The microbiome responds to physicochemical changes in the environment, making it a sensitive indicator of ecosystem status. Monitoring microbial communities in aquatic systems is therefore essential for understanding ecosystem health and responses to... read more
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