AI Medical Compendium

HCAR1 antagonist screening based on boundary-selected negative sampling strategy and multi-level graph neural network.

Computer methods and programs in biomedicine Jan 24, 2026

BACKGROUND AND OBJECTIVE: Hydroxycarboxylic acid receptor 1 (HCAR1), also known as the lactate receptor, is closely associated with tumorigenesis and cancer progression due to its aberrant activation, making it an attractive therapeutic target for ca... read more

A machine learning model for predicting complete virological response in chronic hepatitis B patients receiving first-line nucleos(t)ide analogues therapy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Jan 24, 2026

BACKGROUND: Complete virological response (CVR) is the primary goal of nucleos(t)ide analogues (NAs) therapy for chronic hepatitis B (CHB) patients. The objective of this study was to develop and validate a machine learning (ML) model to predict CVR ... read more

Computational identification of potential MMP-2 inhibitors in cancer using machine learning, molecular docking, and dynamics simulations.

Computational biology and chemistry Jan 24, 2026

Matrix metalloproteinase-2 (MMP-2) is a zinc-dependent endopeptidase which plays a key role in the extracellular matrix-remodeling and cancer metastasis. Nevertheless, despite the vast number of attempts, MMP-2 selective and low-toxicity development ... read more

IKDP: Implicit Knowledge Enhanced Disease Prediction via heterogeneous admission sequence graphs.

Artificial intelligence in medicine Jan 24, 2026

Despite significant advances in deep learning for electronic health record (EHR) modeling, accurately representing complex disease relationships and admission trajectories remains challenging. Current approaches that leverage external knowledge graph... read more

Insights into red sea bream iridovirus pathogenesis: Unveiling host-pathogen interactions using membrane yeast two-hybrid and molecular dynamics.

Bioorganic chemistry Jan 24, 2026

Red sea bream iridovirus (RSIV), a member of the genus Megalocytivirus, poses a substantial threat to global aquaculture through its infection of marine fish species. The major capsid protein (MCP) represents the principal immunogenic component of RS... read more

Machine learning-assisted ratiometric fluorescent sensing platform based on antenna effect in Tb-doped metal-organic framework for visual quantification of enoxacin.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Jan 24, 2026

In this work, a ratiometric fluorescent sensing platform based on the antenna effect in Tb-doped metal-organic framework (Tb-MOF) was constructed for sensitive and visual detection of enoxacin (Eno). The coordination of Tb3+ with the β-diketone struc... read more

MoistureVision: Rapid non-destructive prediction of cotton seed moisture using hyperspectral imaging and machine learning.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Jan 24, 2026

Rapid, non-destructive and accurate prediction of cotton seed moisture content is important for assessing seed vigour and improving storage capacity. In this study, a prediction approach for cotton seed moisture content was developed based on machine... read more

Reaffirming Bedside Shock Recognition through Machine-Learning Refinement.

Indian journal of pediatrics Jan 24, 2026

PHLDB1 and WDFY4 as dual-state biomarkers in SLE pathogenesis and lupus nephritis prediction.

BMC immunology Jan 24, 2026

OBJECTIVES: Our previous study confirmed systemic lupus erythematosus (SLE) associated with polymorphisms of PHLDB1 and WDFY4 genes. In this study, we investigatedthe clinical relevance of PHLDB1 and WDFY4 in SLE pathogenesis and their potential as b... read more

Can large language models provide quality, reliable and readable information about sudden infant death syndrome?

BMC pediatrics Jan 24, 2026

Artificial Intelligence Medical Compendium