Background: Major depressive disorder (MDD) is a neuro-immune-metabolic-oxidative (NIMETOX) disorder. Nevertheless, the effects of alterations in immune responsiveness, oxidative stress, antioxidant defenses, gut-derived short-chain fatty acids (SCFA... read more
Protein expression within oncogenic or suppressive pathways is a hallmark indicator of oncogenesis. While traditional AI models in digital pathology attempt to predict singular proteins, there is a need to predict the downstream expression of protein... read more
Background Patients with repaired tetralogy of Fallot (rTOF) require lifelong surveillance with cardiovascular magnetic resonance (CMR) and cardiopulmonary exercise testing (CPET). However, results are frequently stored as unstructured free-text repo... read more
Background: Sarcopenia is associated with mortality and morbidity following acute ischemic stroke (AIS), but the diagnosis requires specialized equipment or time-consuming assessments. Computed tomography (CT) measures of temporal muscle volume (TMV)... read more
Background Stress cardiomyopathy (SCM) shares features with acute myocardial infarction (AMI) which may lead to misdiagnosis and misaligned management decisions. We hypothesize that features derived from the 12-lead ECG can identify cases of SCM and ... read more
Chronic wounds affect over 1.2 million Canadians and incur healthcare costs exceeding $13 billion annually, with global expenditures approaching $149 billion. Current clinical practice relies on manual measurements and subjective visual evaluations, ... read more
Purpose: Natural Language Processing (NLP) has the potential to extract structured clinical knowledge from unstructured Electronic Health Records (EHRs). However, the limited availability of annotated datasets for algorithm training restricts its app... read more
Background: Early and accurate identification of cardiac amyloidosis improves patient outcomes, yet relevant evidence is frequently hidden in free-text records. This study assesses whether structured variable extraction or direct free-text analysis m... read more
Linking (BEL) are essential for transforming unstructured Electronic Health Records (EHRs) into structured information. However, tools for these tasks are limited in non-English biomedical texts such as Dutch and Italian. This study investigates the ... read more
Background Genome-wide association studies (GWAS) have identified numerous risk loci for Parkinson's disease, yet identifying causal genes and mechanisms remains challenging due to non-coding associations and complex linkage disequilibrium. Methods W... read more
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