Introduction: To improve upon the World Health Organization (WHO) 8 danger signs used to identify young infants (<2 months) requiring referral during community health worker (CHW) home visits, aggregative features (e.g., cumulative visits with fever)... read more
Aims: Despite the availability of clinical risk scores for atherosclerotic cardiovascular disease (ASCVD), their use is limited because the required predictor data are often missing. We developed and validated ECG-ASCVD, a scalable risk prediction pa... read more
Background Beta diversity quantifies pairwise differences between two or more communities through matrix transformations, which are either naive to phylogeny or phylogenetically aware. Methods have recently been introduced that also consider composit... read more
B-cell maturation antigen (BCMA) shedding by {gamma}-secretase generates soluble BCMA (sBCMA) , which diminishes membrane antigen density, and limits the durability of BCMA-directed immunotherapies in multiple myeloma (MM). Here, using AI-driven diff... read more
Effective management of Bovine Respiratory Disease Complex (BRDC) requires timely, non-invasive diagnostic tools to protect calf health and welfare. Among early clinical signs, coughing stands out as both frequent and informative. To explore its pote... read more
Understanding and engineering T-cell receptor (TCR) specificity is central to personalized immunotherapy and antigen discovery. However, while antigen-conditioned TCR design approaches have begun to emerge, most frameworks still focus on scoring cand... read more
Glycosphingolipids (GSLs) are essential components of biological membranes with important roles in cell signalling. Disrupted GSL metabolism is associated with malignancy across a range of cancers, with different GSLs implicated in distinct tumours. ... read more
Motivation: The rapid success of deep learning sequence-to-function (S2F) models has driven a trend toward ever larger architectures for regulatory genomics. While these models achieve meaningful predictive performance, their growing size and computa... read more
Systematic identification of functional non-coding regulatory variants remains a major challenge in human genetics. Conventional approaches such as large-scale CRISPR screening and genome-wide association studies (GWAS) are powerful but often prohibi... read more
Prevailing models aiming at explaining heading assume that humans need to recover the Focus of Expansion (FOE) while filtering out rotational flow (curl) caused by eye movements. We propose an alternative: the visual system utilizes retinal curl dire... read more
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