AI Medical Compendium

Characterization and Substrate Specificity of a Recombinant Acetyl Xylan Esterase from Halalkalibacterium halodurans through a Dual-Strategy Rational Design.

Journal of agricultural and food chemistry Jan 23, 2026

Acetylxylan esterases (AXEs) hydrolyze acetyl groups in xylan but are limited by their narrow substrate specificity. To improve their industrial applications, we engineered a CE7 family HhAXE from Halobacillus halodurans. The purified enzyme exhibite... read more

Nanopore Single-Molecule Chemistry.

Annual review of biophysics Jan 23, 2026

Nanopores have become transformative tools in single-molecule chemical analysis, enabling detailed interrogation of molecular interactions and reaction dynamics. These advancements have revolutionized the characterization of chemical kinetics and ste... read more

Deep learning assessment of fetal brain maturation on 3D ultrasound volumes in early-onset fetal growth restriction.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Jan 23, 2026

OBJECTIVES: To quantify fetal brain maturation in fetuses with early-onset fetal growth restriction (FGR) by estimating gestational age (GA) based on the appearance of gyrification and individual brain structures from three-dimensional (3D) ultrasoun... read more

Machine Learning Approach Enables Highly Accurate Identification of At-Risk Metabolic Dysfunction-Associated Steatohepatitis.

Hepatology research : the official journal of the Japan Society of Hepatology Jan 23, 2026

AIM: At-risk metabolic dysfunction-associated steatohepatitis (MASH), characterized by significant activity and fibrosis, increases the risk of liver complications. Liver stiffness measurement (LSM), commonly used to detect significant fibrosis, has ... read more

From Tissue Archives to Liquid Biopsy: Transfer Learning for MicroRNA-Based Lung Cancer Diagnosis.

Analytical chemistry Jan 23, 2026

Serum microRNA-based liquid biopsy holds a great application prospect in noninvasive lung cancer diagnosis. However, building an efficient serum-based miRNA classifier remains a challenging issue due to the nearly infinite miRNA combinations and the ... read more

Leveraging Large Language Models to Improve the Readability of German Online Medical Texts: Evaluation Study.

JMIR AI Jan 23, 2026

BACKGROUND: Patient education materials (PEMs) found online are often written at a complexity level too high for the average reader, which can hinder understanding and informed decision-making. Large language models (LLMs) may offer a solution by sim... read more

AI-enhanced multi-timescale optimization strategy for virtual power plants: Advancing losad forecasting and dynamic demand response integration.

PloS one Jan 23, 2026

The integration of renewable energy sources (RESs) introduces significant challenges related to uncertainty and intermittency in power grids. While Artificial Intelligence (AI) offers promising solutions for Virtual Power Plants (VPP) optimization, e... read more

Plasma Proteomic Profiling Identifies a Six-Protein Panel for Grading and Predicting Intervertebral Disc Degeneration.

Journal of proteome research Jan 23, 2026

Intervertebral disc degeneration (IDD) represents a significant health concern affecting a large portion of the population and leads to chronic pain and disability. Despite the prevalence of this condition, the underlying biological mechanisms and po... read more

Recovery of expected salary estimated by facial emotion scores against computer-based landscape data.

PloS one Jan 23, 2026

The perceived recovery of expected salary (RES) matters for work efficacy at a given amount of wage investment. A total of 31 industrial parks (IPs) were randomly chosen from North China. Employees' facial photos were obtained from social networks an... read more

UV-DOAS Combined with Spectral Projection Decoupling Neural Network (SPDNN): An Online System for the Simultaneous Detection of Ammonia and Isoprene at Sub-ppb Levels.