The human genome is partitioned at different levels of 3D genome organization, with topologically associating domains (TADs) being among the most well-known and biologically important structures. TAD boundary disruption is associated with a wide rang... read more
The escalating crisis of antimicrobial resistance poses a devastating and immediate threat to human life. Antimicrobial peptides (AMPs) are a promising antibiotic substitute to combat antimicrobial resistance. Compared with the traditional wet-lab sc... read more
Accurate prediction of antibody-antigen (Ab-Ag) complexation is crucial for understanding immune responses, diagnostics, and the development of therapeutic antibodies. While molecular docking generates conformations, current scoring functions struggl... read more
Background: Right ventricular (RV) function is an important predictor of morbidity and mortality in various cardiovascular conditions. Nevertheless, its echocardiographic assessment is challenging due to its complex anatomy and location in the chest,... read more
Freezing of gait (FoG) prediction is clinically meaningful only when warnings arrive sufficiently early for subsequent action. Therefore, we adopt a Freezing Prediction Horizon (FPH) evaluation that reports prediction performance as a function of the... read more
Abstract Purpose: Glaucoma, a leading cause of irreversible vision loss, often remains undiagnosed due to its asymptomatic progression and the limitations of existing screening methods. This study aimed to validate an artificial intelligence machine ... read more
Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI generated data. However, the clinical consequences... read more
Motivation: Medical documents are a crucial resource for medical research around the world. While troves of valuable health data exist, they are largely computationally inaccessible as hard copies of unstructured text, often with degraded quality due... read more
Antiphospholipid syndrome (APS) and systemic sclerosis (SSc) are immune-mediated multisystem autoimmune diseases with distinct clinical phenotypes but overlapping pathogenic themes, including immune dysregulation, chronic inflammation, and endothelia... read more
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