Cognitive decline, an early indicator of neurodegenerative disorders, presents a growing public health challenge. This study aimed to integrate causal inference and machine learning to quantify the causal impact of high-risk status on cognitive funct... read more
Gout, often comorbid with sleep disorders (SDs), is prevalent in inflammatory arthritis. This comorbidity is notable in patients with impaired renal function requiring blood purification, with unclear underlying mechanisms. This study integrated tran... read more
In glioma research, identifying key molecules for predicting patient prognosis is challenging due to high heterogeneity. This study explores the correlation between alternative splicing (AS) and glioma prognosis, aiming to identify molecular markers ... read more
Generative pretrained transformer 4 (GPT-4) has demonstrated strong performance in standardized medical examinations but has limitations in real-world clinical settings. To address these limitations, the multimodal GPT-4o model integrates text and im... read more
Current opinion in structural biology
Jan 23, 2026
Protein design has the potential to revolutionize biotechnology and medicine. While most efforts have focused on proteins with well-defined structures, increased recognition of the functional significance of intrinsically disordered regions, together... read more
BACKGROUND: Timely identification and transfer of critically ill patients to intensive care units (ICUs) are crucial to reducing morbidity and mortality. Delayed ICU admission is linked to higher mortality, emphasizing the need for efficient predicti... read more
OBJECTIVE: Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play a significant role in renal cell carcinoma (RCC) progression and treatment response. However, current methods for evaluating CAFs infiltra... read more
The "Greening Earth" and rising aridity are both climate change signatures. We investigate the response of global photosynthesis to moisture stress (higher demand and lower availability of moisture) in current (2000-2021) and future climate scenarios... read more
Chemical fingerprinting is a key environmental forensics technique used in oil spill investigations to identify the source and type of oil in spill residues. Conventional approaches rely on detecting individual petroleum biomarkers in gas chromatogra... read more
Open cattle feedlots are major animal feeding operations in the United States, characterized by outdoor confinement, high stocking densities, and regulated feeding practices. However, a comprehensive national database of these facilities remains limi... read more
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