As the most common pediatric brain malignancy, medulloblastoma (MB) includes multiple distinct molecular subtypes characterized by clinical heterogeneity and genetic alterations. Accurate identification of MB subtypes is essential for downstream risk... read more
Trends in endocrinology and metabolism: TEM
Jan 22, 2026
The metabolite substrates of numerous transporters remain largely elusive. Two recent studies by Khan et al. and Dias et al. identify SLC25A45 as a mitochondrial transporter of methylated amino acids that supports de novo carnitine synthesis, providi... read more
High-throughput, label-free monitoring of cellular differentiation remains a major challenge in stem cell biology and regenerative medicine. Raman spectroscopy offers rich molecular specificity without perturbing the cell state, but the analytical co... read more
BACKGROUND: Conflict of interest (COI) management is critical for ensuring the scientific integrity and fairness of clinical practice guidelines (CPGs). Large language models (LLMs) have great potential in strengthening COI management, particularly i... read more
Co-fractionation mass spectrometry (CF-MS) enables large-scale profiling of endogenous protein-protein interactions, yet CF-MS data generation is of low throughput and therefore predictive models are often limited by the scarcity and limited diversit... read more
Deciphering the cis-regulatory logic underlying cell type identity remains a key challenge in biology. Single-cell chromatin accessibility (scATAC-seq) atlases enable training of sequence-to-function (S2F) deep learning models to decode enhancer logi... read more
The postnatal white matter connectome undergoes profound reorganization, yet the topological principles governing its spatiotemporal maturation remain largely unknown. Using connectome mapping, machine learning, and neurobiological annotation, we sho... read more
The paper describes the dataset for a deeper evaluation of the machine learning models for handwritten character recognition. For that purpose, we build a dataset that, combined with existing NIST Databases, offers possibilities for additional analys... read more
Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer's disease (AD), but its role in retinal pathology and disease progression is unclear. Here we identify Chlamydia pneumoniae inclusions in the retina, showing higher burden in ... read more
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