Neuromorphic visual devices have emerged as a critical strategy to address the limitation of the von Neumann bottleneck. However, the role of interfacial molecular engineering-specifically the modulation of polar groups in polymer gate dielectrics-in... read more
Early achievement of deep remission improves patients' outcome in chronic myeloid leukemia (CML) treatment, highlighting the need for predictive indicators before therapy initiation. This study aimed to develop a tool to predict CML treatment respons... read more
Importance: Emerging evidence suggests healthcare AI systems may exhibit deceptive alignment (appearing safe during validation while optimizing for misaligned objectives in deployment) and evaluation awareness (detecting and adapting behavior during ... read more
Purpose: Nearly all amyotrophic lateral sclerosis (ALS) patients develop dysarthria, with many progressing to anarthria and global expressive communication failure despite preserved consciousness. Despite the severity of this communication loss, avai... read more
Purpose: Studies based on electronic health records (EHR) often rely on structured data, which may incompletely capture important clinical phenotypes in EHR notes. The purpose of this study was to assess two natural language processing (NLP) tools to... read more
Early and accurate diagnosis of Alzheimer's Disease (AD) is critical for effective intervention. While previous studies have explored speech-based biomarkers for AD, this paper presents the first systematic investigation of acoustic, prosodic, and ph... read more
Parkinson's disease disproportionately affects males; however, the cause of this sex difference is unknown. We found that expressing mutant -synuclein A53T in Drosophila dopamine neurons recapitulates the sex differences observed in human Parkinson's... read more
The druggable genome encompasses the genes that are known or predicted to interact with drugs. The Drug-Gene Interaction Database (DGIdb) provides an integrated resource for discovering and contextualizing these interactions, supporting a broad range... read more
Enzyme activity and stability are strongly modulated by pH, making the catalytic pH optimum (pH opt) a key parameter in enzyme development and biotechnological applications. Experimental determination of pH opt is, however, labor-intensive and time-c... read more
Ancestral sequence reconstruction (ASR) is a foundational task in evolutionary biology, providing insights into the molecular past and guiding studies of protein function and adaptation. Conventional ASR methods rely on a multiple sequence alignment ... read more
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