International journal of medical informatics
Jan 19, 2026
BACKGROUND: Patient recruitment for clinical trials remains a major challenge, with 86% of trials failing to meet enrollment targets on time. In over 77% of cases, recruitment difficulties stem from matching problems between trials and patients. Case... read more
Insects feeding on xylem sap, such as adult Aphrophoridae spittlebugs, are vectors of the plant pathogenic xylem-limited bacterium Xylella fastidiosa (Xf), a causal agent of a number of severe diseases, including the Olive Quick Decline Syndrome (OQD... read more
OBJECTIVE: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined. This study aim... read more
BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy originating from the epithelial lining of second-order bile ducts. Despite advances in immunotherapy, which underscore the pivotal roles of T-cell dynamics and tumor micro... read more
BACKGROUND: Sepsis is common and deadly, and subtypes are proposed to guide precision treatment. However, little is known about the uncertainty in subtype classification, and its implications for trajectory and treatment response. METHODS: In multipl... read more
With the increasing use of artificial intelligence (AI) in higher music education, there is a growing need to evaluate whether intelligent feedback systems can meaningfully enhance expressive piano performance. This study investigates the research qu... read more
BACKGROUND: The specific anatomy of bicuspid aortic valve (BAV) increases the incidence of ≥ mild paravalvular leakage (PVL) after transcatheter aortic valve replacement (TAVR). OBJECTIVES: The purpose of this study was to develop and validate a mode... read more
BACKGROUND: Transcatheter tricuspid valve intervention (TTVI) has emerged as a valuable therapeutic option for patients with severe tricuspid regurgitation. However, the impact of TTVI on right ventricular (RV) function remains incompletely understoo... read more
Accurate classification of hematopoietic cancer subtypes remains challenging due to the multipotent nature of hematopoietic cells and the absence of definitive genetic markers. To address this, we propose a Transformer-based Autoencoder that captures... read more
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