In the field of materials science, using diverse experimental and computational methods is a well-known approach as the most effective route to comprehensive material characterization. Combining high-resolution transmission electron microscopy (TEM) ... read more
BACKGROUND: Chronic kidney disease (CKD) is getting more common in elderly people with metabolic syndrome, but early detection and risk prediction are still hard. So we created and validated a CKD risk prediction model tailored for these patients to ... read more
Mayo Clinic proceedings. Digital health
Jan 19, 2026
OBJECTIVE: To evaluate the effectiveness of the artificial intelligence-based qXR lung nodule malignancy score (qXR-LNMS) in detecting high-risk incidental pulmonary nodules (IPNs) on chest X-rays (CXRs). PATIENTS AND METHODS: The CREATE (NCT05817110... read more
This study reviews radiographic data segmentation as a cornerstone of machine learning (ML) and deep learning (DL) in dentistry. After outlining artificial intelligence (AI), ML, and DL concepts, it highlights convolutional neural networks-driven tas... read more
Reinforcement learning approaches for therapeutic peptide generation suffer from mode collapse, converging to narrow regions of sequence space even when explicit diversity penalties are applied. Fine-grained analysis reveals persistent mode-seeking b... read more
Peptides, as therapeutic molecules, offer unique advantages in targeting complex protein surfaces, yet their rational design remains limited by the vastness of the sequence space and the constraints of traditional approaches. Here, we propose High-Pe... read more
IMPORTANCE: The Drug-Gene Interaction Database (DGIdb) has a long history of driving hypothesis generation for biomedical research through the careful curation of drug-gene interaction data from primary and secondary sources with supporting literatur... read more
Background Genome-wide CRISPR screening has enabled the development of dependency maps in hundreds of cancer cell lines, facilitating the identification of genetic vulnerabilities associated with specific biomarkers. Paralogs, despite being common dr... read more
Introduction: Reliable estimation of mortality among critically ill patients is crucial for guiding clinical decisions and optimizing ICU performance. Traditional scoring systems such as APACHE, SOFA, and SAPS are commonly applied, though their predi... read more
Background and Aims: Pragmatic clinical trials are designed to assess interventions in real-world settings, and their broad inclusion criteria and clinical variability create valuable opportunities for exploring heterogeneity of treatment effects. In... read more
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