Predicting antibody-antigen binding affinity is critical for therapeutic development, but machine learning-based approaches to the problem are typically hampered by the small amount of available structural and affinity data. We introduce SE3Bind, an ... read more
Background: Cancer research emphasises early detection, yet quantitative methods for analysing normal tissue remain limited. Hematoxylin and eosin (H&E)-stained tissues in digitised whole slide images (WSIs) enable computational histopathology; howev... read more
Animals integrate knowledge about how the state of the environment evolves to choose actions that maximise reward. Such goal-directed behaviour - or model-based (MB) reinforcement learning (RL) - can flexibly adapt choice to changes, being thus disti... read more
Orphan genes - genes lacking detectable homologs outside a species - are widespread in microbial genomes and are thought to contribute to their adaptation and molecular innovation. However, not all predicted orphan genes may represent novel functiona... read more
Speech representations in the human brain do not simply mirror the instantaneous speech signal; rather, they display several properties that are hypothesized to facilitate the integration of speech sounds into words. In particular, neural encodings o... read more
Medication product names in Swiss electronic health records are heterogeneous and often encode multiple attributes (e.g., ingredient, strength, dose form, packaging) in German free text. This limits interoperability and reduces the utility of ATC cod... read more
"Black box" deep learning models for medical image interpretation limit clinical trust and analysis of performance degradation. Here, we introduce Concept-Level Embeddings for Auditable Radiology (CLEAR), an auditable foundation model based on clinic... read more
Background: Integrating advanced artificial intelligence (AI) into clinical decision-support often requires the sharing of sensitive patient data with external services, raising privacy concerns. Homomorphic encryption (HE) allows computing directly ... read more
Skin diseases manifest as visually observable eruption patterns, making image-based assessment a central component of dermatological diagnosis. While recent artificial intelligence (AI)-based approaches have achieved remarkable progress in classifyin... read more
We propose EmoLat, a novel emotion latent space that enables fine-grained, text-driven image sentiment transfer by modeling cross-modal correlations between textual semantics and visual emotion features. Within EmoLat, an emotion semantic graph is co... read more
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