Deep learning is revolutionizing enzyme engineering through efficient residue redesign. Leveraging deep learning for enzyme engineering, we redesigned a pectinase using ProteinMPNN guided by multiple sequence alignment. Our top-performing variant, DS... read more
International journal of pharmaceutics
Jan 17, 2026
Creating high-quality datasets for training machine learning models in specialized domains like pharmaceutical research is often constrained by the manual effort required to extract and compute critical parameters from heterogeneous literature. A nov... read more
Chronic kidney disease (CKD) is a leading cause of death worldwide. Currently available drugs slow but do not cure or prevent progression to end-stage kidney disease. Unfortunately, dialysis and kidney transplant not only pose severe lifestyle constr... read more
Gynecologie, obstetrique, fertilite & senologie
Jan 17, 2026
Cardiotocography (CTG) is defined as the simultaneous recording of fetal heart rate and uterine contractions. It is used worldwide during labour to assess foetal well-being and to detect early signs of hypoxia. However, its interpretation relies main... read more
Real-time monitoring of total organic carbon (TOC) is essential for assessing water quality, optimizing treatment processes, and safeguarding aquatic ecosystems. This study reports the development of a compact LED-SiPM fluorescence sensor, integrated... read more
BACKGROUND: Post-percutaneous coronary intervention (PCI) Murray's law-based quantitative flow ratio (μFR) is associated with long-term clinical outcomes. A tool capable of accurately predicting post-PCI μFR before intervention could support procedur... read more
BACKGROUND: Machine learning prediction models require prospective validation to ensure implementation fidelity and feasibility. Our primary objective was to prospectively validate a previously reported postoperative mortality prediction model in inp... read more
Journal of the World federation of orthodontists
Jan 17, 2026
OBJECTIVE: Precise identification of tooth and gingival boundaries in digital models is essential for effective orthodontic diagnosis, treatment planning, and appliance fabrication. Recent advances in artificial intelligence (AI) offer opportunities ... read more
BACKGROUND: Traditional patient education often lacks personalization and engagement, potentially limiting knowledge acquisition and treatment adherence[1]. Advances in artificial intelligence (AI), including voice cloning technology and large langua... read more
Staphylococcus aureus is a leading cause of nosocomial infections, including sepsis, bacteraemia, pneumonia, and endocarditis, and continues to pose a major public health challenge due to escalating multidrug resistance and the absence of an effectiv... read more
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