Food fraud through false declarations of geographical origin poses major economic and regulatory challenges, particularly for commodities subject to trade restrictions or premium provenance labeling. Fresh garlic (Allium sativum L.), a globally trade... read more
Genome-wide association studies have linked millions of genetic variants to biomedical phenotypes, but their utility has been limited by lack of mechanistic understanding and widespread epistatic interactions. Recently, Transformer models have emerge... read more
Aging, the leading risk factor for numerous diseases, manifests through diverse structural and architectural changes in human tissues, providing an opportunity to quantify and interpret tissue-specific aging. To address this, we present a comprehensi... read more
Deep visual proteomics (DVP) is an emerging approach for cell type-specific and spatially resolved proteomics. However, its broad adoption has been constrained by the lack of an open-source end-to-end workflow in a community-driven ecosystem. Here, w... read more
ObjectiveOur goal was to create open-source software for closed-loop EEG-TMS that allows researchers to rapidly prototype and develop novel stimulation paradigms in a high-level programming language. This addresses the limitations of current solution... read more
1Reconstructing genomes from metagenomic assemblies is foundational to microbiome research, yet metagenome binning remains constrained by a persistent trade-off between genome fidelity and deployable throughput. Many high-accuracy approaches rely on ... read more
Computational protein design using machine learning models has advanced rapidly since the introduction of AlphaFold2. There is now a suite of tools that enable in silico design of proteins with desired structures and properties. Most design workflows... read more
Alcohol Use Disorder (AUD) is a prevalent and debilitating neuropsychiatric condition characterized by compulsive alcohol consumption, impaired control, and negative emotional states, affecting about 28 million adults in the United States. Despite it... read more
Adaptive behavior requires inferring latent context and rapidly adjusting decisions in response to changing environmental contingencies. We investigated how reward context is learned, represented, and updated during decision making. We recorded large... read more
Lupus nephritis (LuN) and renal allograft rejection (RAR) manifest inflammation and fibrosis that ultimately lead to kidney failure. To quantitatively assess spatial injury patterns, we collected high dimensional spatial proteomics data from 23 LuN, ... read more
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