The meta-analysis's utility is dependent on previous studies having accurately captured the variables of interest, but in medical studies, a key decision variable that impacts a physician's decisions was not captured. This results in an unknown effec... read more
In this paper, we propose difficulty-guided sampling (DGS) to bridge the target gap between the distillation objective and the downstream task, therefore improving the performance of dataset distillation. Deep neural networks achieve remarkable perfo... read more
Computational protein design using machine learning models has advanced rapidly since the introduction of AlphaFold2. There is now a suite of tools that enable in silico design of proteins with desired structures and properties. Most design workflows... read more
Alcohol Use Disorder (AUD) is a prevalent and debilitating neuropsychiatric condition characterized by compulsive alcohol consumption, impaired control, and negative emotional states, affecting about 28 million adults in the United States. Despite it... read more
Adaptive behavior requires inferring latent context and rapidly adjusting decisions in response to changing environmental contingencies. We investigated how reward context is learned, represented, and updated during decision making. We recorded large... read more
Lupus nephritis (LuN) and renal allograft rejection (RAR) manifest inflammation and fibrosis that ultimately lead to kidney failure. To quantitatively assess spatial injury patterns, we collected high dimensional spatial proteomics data from 23 LuN, ... read more
Proteins execute cellular functions through a structural continuum ranging from stable, folded domains to highly dynamic intrinsically disordered regions (IDRs). Conformational ensembles represent the set of three-dimensional structures a protein ado... read more
Numerous applications in research and medicine rely on reliable identification and quantification of virus-infected cells. Current methods either apply reporter viruses, that often differ from clinical isolates (e. g. cell tropism, immune evasion) or... read more
Three-dimensional electron microscopy (3D EM) enables the quantitative analysis of cellular ultrastructure. However, large-scale segmentation of whole-cell volumes poses a significant challenge, especially in biologically diverse systems. Unlike medi... read more
BackgroundThe ATN (Amyloid/Tau/Neurodegeneration) framework provides a theory-driven approach to Alzheimers disease (AD) classification using binary biomarker cutoffs, while unsupervised machine learning offers data-driven phenotyping. The concordanc... read more
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