Passive Acoustic Monitoring (PAM) has advanced ecological research by enabling non-invasive recordings of wildlife vocalizations that provide insight into species presence, behavior, and reproductive activity. This remote-sensing approach is particul... read more
The study of neuronal activity is essential for understanding brain function and its alterations in neurodegenerative diseases. Advances in in vivo imaging have enabled real-time observation of neuronal dynamics, but classical statistical methods str... read more
Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for anal... read more
Classifying chromatin loops from 3D genomics data according to their epigenetic and structural attributes is important for inferring their functional roles. Currently, such classification typically relies on the manual intersection of epigenomic sign... read more
Precise cell type targeting is critical for both clinical and experimental applications of adeno-associated viral (AAV) vectors, yet engineering vectors with cell type-specific activity remains a challenge. Here, we compared three strategies leveragi... read more
Deep learning (DL) is increasingly integrated into quantitative ecology, particularly for automating the classification of sensor data in biodiversity monitoring. In addition to substantially reducing data processing effort, DL models often achieve h... read more
Deep learning offers hope for more efficient phylogenetic inference methods. However, it has yet to have the transformative effect on phylogenetics that it has had in other fields. Here we present a novel approach that combines deep learning with con... read more
0Generative artificial intelligence has advanced antibody discovery, yet de novo design of therapeutic antibodies against targets with "zero-prior" epitopes remains a fundamental challenge. We define "zero-prior" epitopes as target sites lacking stru... read more
Biomedical interactions are inherently dynamic, often shifting or even reversing under specific physiological states. However, existing extraction methods simplify these complex mechanisms into context-agnostic binary associations, resulting in seman... read more
The biophysical principles underlying distinct conformational changes in proteins with similar topologies remain poorly understood. Class D G Protein-Coupled Receptors (GPCRs), fungal pheromone-sensing receptors essential for mating and survival, exh... read more
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