AI Medical Compendium

Programmable Smart CAR-T design: A new paradigm in precision immunotherapy driven by logic gates, conditional activation, allogeneic strategies, and artificial intelligence.

Cancer letters Jan 13, 2026

Chimeric antigen receptor T-cell (CAR-T) therapy has achieved unprecedented success in hematological malignancies but faces formidable challenges in solid tumors. These limitations include severe "on-target, off-tumor" toxicity, antigen heterogeneity... read more

Machine learning for discovery of clinical pain biomarkers following spinal cord injury.

Experimental neurology Jan 13, 2026

Chronic pain is highly prevalent in patients with spinal cord injury (SCI) and further degrades the quality of life in individuals already struggling with somatic, motor, and autonomic deficits. The management of SCI pain is challenging, mainly due t... read more

Measuring trust in artificial intelligence with the N2pc component.

NeuroImage Jan 13, 2026

Efficient allocation of attentional resources is critical when humans collaborate with artificial intelligence (AI): they must focus on their task while monitoring the AI to intervene if it fails. Inefficient allocation-such as excessive monitoring o... read more

CT-free attenuation and scatter correction of [11C]CFT brain PET using a Bi-directional matching network.

NeuroImage Jan 13, 2026

Quantitative PET imaging requires accurate attenuation and scatter correction (ASC), but the standard CT-based method introduces additional radiation exposure-a significant concern for neurological studies involving repeated scans. Here we applied an... read more

AI-guided integrative discovery of PD-1/PD-L1 interface inhibitors through multiscale modeling and experimental validation.

International journal of biological macromolecules Jan 13, 2026

The PD-1/PD-L1 protein-protein interaction (PPI) is a critical immune checkpoint, and its inhibition represents a powerful strategy in oncology. Disrupting this macromolecular complex with small molecules remains a significant challenge. This study e... read more

Soil organic carbon sequestration efficiency with biochar addition across the croplands of China: A perspective from particulate and mineral-associated organic carbon.

Environmental research Jan 13, 2026

Soil organic carbon (SOC) is typically fractionated into particulate and mineral-associated organic carbon (POC and MAOC). Biochar has been widely deployed to improve soil fertility, crop yield, and carbon sequestration. Organic carbon sequestration ... read more

Action tremor kinematics exhibit features of stabilization dysfunction in essential tremor patients.

Journal of neuroscience methods Jan 13, 2026

BACKGROUND: Action tremor that begins with voluntary movement is a common manifestation of essential tremor (ET). We investigated a novel approach to detect reach direction and tremor direction across naturalistic reaches, elucidating this relationsh... read more

Reply to Commentary on ``Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma''.

American journal of ophthalmology Jan 13, 2026

The 2025 top 10 list of endoscopy topics in medical publishing: an annual review by the American Society for Gastrointestinal Endoscopy Editorial Board.

Gastrointestinal endoscopy Jan 13, 2026

Using a systematic literature search of original articles published during 2025 in Gastrointestinal Endoscopy (GIE) and other high-impact medical and gastroenterology journals, the GIE Editorial Board of the American Society for Gastrointestinal Endo... read more

The gut microbiota dysbiosis in geriatric multimorbidity: Pharmacotherapeutic implications, pathophysiological mechanisms, and precision modulation strategies.

Ageing research reviews Jan 13, 2026

Aging around the world is accelerating. With that comes the intersection of geriatric multimorbidity and polypharmacy, creating a large uncertainty about the pharmacological efficacy and therapeutic consequences of medications used when multiple conc... read more

Artificial Intelligence Medical Compendium