Artificial Intelligence Medical Compendium

OBJECTIVE: To determine whether plasma and serum extracellular vesicles (EV) are interchangeable for immunoaffinity-enriched proteomic profiling in high-grade serous ovarian cancer (HGSOC), and whether an EV protein signature improves diagnostic perf... read more 

Clinical Artificial Intelligence (AI) tools are frequently developed in academic centres yet deployed in community hospitals with different workflows, staffing, and oversight. In Canada, where community hospitals constitute approximately 90% of hospi... read more 

In this Voices article, six investigators reflect on the growing role of artificial intelligence (AI) in molecular biology research. They discuss AI's potential to accelerate discovery, enhance data analysis, and generate new hypotheses, while also h... read more 

In a recent issue of Cell, Adduri et al.1 introduce State, a machine learning model that generalizes across different cellular contexts and predicts how single-cell transcriptomes respond to genetic or chemical perturbations. read more 

Since the discovery of the clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) system, genome-editing technologies have advanced rapidly, and the field has expanded substantially. In parallel, artificial intelligence (A... read more 

We are just over a decade into the single-cell revolution in biology, which has been coupled to the growing use of artificial intelligence (AI) in single-cell genomics. Most early single-cell RNA embedding models and subsequent "foundation models"-re... read more 

Cis-regulatory elements (CREs) integrate signals from transcription factors (TFs) to control gene expression, yet mechanisms underlying this information processing remain poorly understood. Deep learning demonstrates expression is predictable from CR... read more 

Driven by advances in artificial intelligence, de novo protein design can now generate diverse molecular functions from the ground up, achieving remarkable success in engineering binders against many macromolecular targets. Here, we provide a perspec... read more 

Recent whole-brain cell atlases have uncovered a consistent cytoarchitectural feature: the greatest diversity of discrete neuronal cell types resides not in the regions with the most neurons (e.g., the cortex and cerebellum) but rather in deep subcor... read more 

Accurate identification of immunogenic neoantigens remains a bottleneck in personalized cancer vaccine development, particularly in low-mutation-burden tumors such as pancreatic ductal adenocarcinoma (PDAC). We developed NeoBridge, a hybrid ensemble ... read more